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2012, Number 2

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Rev Educ Bioquimica 2012; 31 (2)

Modulación de la expresión de enzimas del citocromo P450 hepáticas durante las etapas fetal y pediátrica

Molina OD, Camacho CR, Domínguez RAM, Vences MA

Language: Spanish
References: 36
Page: 60-71
PDF size: 539.27 Kb.


ABSTRACT

The Cytochromes P450 (CYP450) are the principal enzymes of phase I involved in the metabolism of xenobiotics and endogenous substrates. CYP450 1, 2 and 3 families play a crucial role in the metabolism and excretion of drugs. Members of CYP450 1 and 2 are absent or in low concentration in fetal stage; their expression are increased after birth until they reach the highest quantity in the adult phase. While members of the family CYP450 3 are the major CYP450 in human liver at all stages of development. Changes in expression of CYP450 in different period of human development can contribute to drug response and/or toxicological effects of them. This review integrates information about the expression of CYP450 enzymes hepatic during fetal development to adulthood.


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