medigraphic.com
ISSN 1028-4796 (Print)

2011, Number 2

Next >>

Rev Cubana Plant Med 2011; 16 (2)

Ethnopharmacological validation of Nectandra coriacea (Sw.) Griseb. and Caesalpinia bahamensis Lam. reported as diuretics in Santa Clara municipality

Pérez MM, Morón RF, Sueiro OML, Boffill CM, Lorenzo MG, Méndez OOR, Blanco MF

Language: Spanish
References: 23
Page: 115-134
PDF size: 221.97 Kb.


ABSTRACT

Introduction: there are in Cuba about 179 plants that the population uses as diurectics, but the effect of the majority of them has not been experimentally confirmed.
Objective: to verify the pharmacological effect attributed to medicinal plants reported as diuretics, whose effect has not been validated yet.
Methods: a two-phase ethnopharmacological study was conducted in Santa Clara municipality: ehnopharmacological identification and in vivo evaluation of the diuretic action of the most reported plants whose preclinical validation was not confirmed. The ethnopharmacological research study was developed in several places of the refered municipality, using a heterogenous sample made up of different sampling groups. On the basis of the two identified species that have not been experimentally validated, 30% decoctions were prepared and orally administered at a dose of 400 mg/kg, based on the determination of total solid content, to male albine rats weighing 170 to 210 g. The dose was completed with physiological saline solution to reach hydrosaline overload with constant total volume of administration equals to 40 mL/kg PV for both the treated groups and the controls (positive, furosemide at 20 mg/kg and hydrochlorotiazide at 10 mg/kg, and negative controls, 0.9 % sodium chloride). Excreted urine volumen were measured at half and hour, one hour, 2, 3, 4, 5 and 6 hours after the administration and the electrolyte concentrations in the total collected urine at 24 hours.
Results: fourteen plants reported by the population were identified according to their use as diuretics. Ten of them presented with significant level of use over 30% whereas 2 lacked their effect validated (Caesalpinia bahamensis Lam. and Nectandra coriacea (Sw.) Griseb. It was observed that the groups treated with both plants increased the urine volume when compared to the negative control group; being the C. bahamensis action more remarkable.
Conclusions: both plants had diuretic effect at 400 mg/kg dose. The action of C. bahamensis was very similar to that of furosemide, whereas the N. coriacea activity was more similar to that of tiazides.


REFERENCES

  1. Guevara M, González S, Álvarez A. Uso etnomédico de la corteza de Mangifera indica L. en Cuba. Rev Cubana Plant Med. [serie en Internet]. 2008 Ene [citado 5 Mar 2010];9(1): [aprox. 5 p.]. Disponible en: http://scielo.sld.cu/scielo.php?pid=S1028-47962004000100013&script=sci_arttext

  2. González M, Ramírez D. Antecedentes y situación reguladora de la medicina herbaria en Cuba. BLACPMA. 2007;6(4):118-24.

  3. García González M. Legislación en iberoamérica sobre fitofármacos y productos naturales. San José Costa Rica: Universidad de Costa Rica; 2000.

  4. Morón FJ. Plantas medicinales y medicamentos herbarios. En: Farmacología General. La Habana: Ecimed; 2002. p. 195-205.

  5. Pérez M, Cid M, Méndez R. Ensayos clínicos en medicamentos herbarios. Un reto actual para el sistema de salud cubano. Medicentro Electrónica [serie en Internet]. 2006 Jun [citado 21 Jun 2007]; 10(3):[aprox. 3 p.]. Disponible en: http://www.vcl.sld.cu/sitios/medicentro/paginasdeacceso/Sumario/ano2006/v10n3a06.php

  6. Bermúdez A, Velásquez D. Etnobotánica médica de una comunidad campesina del estado Trujillo, Venezuela: un estudio preliminar usando técnicas cuantitativas. Rev Fac Farm Univ Cent Venez. 2002;44:2-6.

  7. Chávez M, Arango N. Informe nacional sobre el estado de la biodiversidad en 1997. t. III. Colombia: Instituto de Investigación de Recursos Biológicos Alexander von Humboldt; 1998.

  8. Roig JT. Plantas medicinales y aromáticas o venenosas de Cuba. La Habana: Editorial Científico-Técnica; 1988. p. 675-6.

  9. Fuentes V, Granda MM, Lemes CM. Estudios fenológicos en plantas medicinales XI. Rev Cubana Plant Med. 2000;5(3):106-13.

  10. Álvarez PA, Calzada E, Batista C. Etnobotánica y propagación de Parmentiera edulis D.C., árbol de uso múltiple en Cuba. Revista Forestal Baracoa. 2010;(29):77-86.

  11. Castiglioni J. Lauráceas argentinas I. Género Nectandra. Bol Soc Argent Bot. 1951;4(1):66-94.

  12. Boffill MA. Plantas medicinales usadas en Cuba con efecto diurético comprobado experimentalmente. Medicentro Electrón [serie en Internet]. 2008 Ene [citado 12 Feb 2010];11(2):[aprox. 4 p.]. Disponible en: http://www.vcl.sld.cu/sitios/medicentro/paginasdeacceso/Sumario/ano2008/v12n1a08/plantas81.htm

  13. Marín-Corba C, Cárdenas-López D, Suárez-Suárez S. Utilidad del valor de uso en etnobotánica. Estudio en el departamento de Putumayo (Colombia). Caldasia. 2005;27(1):89-101.

  14. TRAMIL. [serie en Internet]. República Dominicana: Requerimientos de encuestas. Programa de investigación aplicada a la medicina popular del Caribe. Inc.; 2010 [actualizado 4 Abr 2010; citado 5 Ago de 2005]. Disponible en: http://www.funredes.org/endacaribe/Tramil.html

  15. Bermúdez A, Velásquez D. Etnobotánica médica de una comunidad campesina del estado Trujillo, Venezuela: un estudio preliminar usando técnicas cuantitativas. Rev Fac Farm Univ Cent Venez. 2002;44:2-6.

  16. Lipschitz WL, Haddian Z, Kerpscar A. Bioassay of diuretics. J Pharm Exp Ther.1943;79:110-6.

  17. Kau ST, Keddie JR, Andrews D. A method for screening diuretic agents in the rat. J Pharmacol Meth. 1984;11:67-75.

  18. Beyra A, León MC, Iglesias E. Estudios etnobotánicos sobre plantas medicinales en la provincia de Camagüey (Cuba). Anales Jardín Botánico Madrid. 2008;61(2):185-204.

  19. Abreu OA, Cuellar A. Estrategia en la selección de las plantas medicinales a investigar. Rev Cubana Plant Med. 2008;13(3). Disponible en: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S1028-47962008000300009&lng=es&nrm=iso&tlng=es

  20. Bermúdez A, Kanga F, San Gabino Y. Tradicional use of plant in the population of Santa Clara Municipality. VacciMonitor. 2010;19(2). Disponible en: http://www.finlay.sld.cu/publicaciones/vaccimonitor/Vm2010/vm2010.htm#n5

  21. Boffil M, Lorenzo G, Monteagudo E, Sueiro M, Matos J. Diuretic activity of the medical plants used popularly in Cuba. Pharmacologyonline. 2006;3(1). Disponible en: http://www.unisa.it/download/1966_145_2003256180_39.Boffill2.pdf

  22. Pérez M, Boffill M, Morón F. Ethnopharmacological and preclinical study of diuretic effect of the most used plants by Cuban population. VacciMonitor. 2010;19(2). Disponible en: http://www.finlay.sld.cu/publicaciones/vaccimonitor/Vm2010 /vm2010.htm#n5

  23. Sueiro ML, Ribalta V, González Y, Hernández E. Evaluation of diuretic activity from Dichrostachys cinerea (L.) Wight & Arn. leaves and bark aqueous extracts. VacciMonitor. 2010;19(2). Disponible en: http://www.finlay.sld.cu/publicaciones/vaccimonitor/Vm2010/vm2010.htm#n5




2020     |     www.medigraphic.com