Pérez JL, Castillo AA, Salas MH, Puente ZE, Betancourt HJ, Jackson HE, Mora TY

Language: Spanish
References: 10
Page: 390-395
PDF size: 38.15 Kb.

ABSTRACT

Introduction: Solanum torvum Sw., traditionally known as prendejera, is a medicinal plant used by the population as antimicrobial and anti-inflammatory agent among other properties. No acute toxicity studies are reported on this plant, just long-term toxicity studies.
Objectives: to evaluate the acute oral toxicity by the class method using decoction of Solanum torvum leaves and stems orally administered to Sprague Dawley rats.
Methods: an acute oral toxicity test based on the class method was conducted. The S.torvum plant decoction was administered in one dose of 2000 mg/kg of body weight. Pathological anatomy studies were performed to analyze the toxicity in the tested substance.
Results: the evaluated substance did not show any clinical signs of toxicity or animal deaths; no alterations in the body weight of the experimental models were found. There were no alterations of diagnostic value according to the macroscopic analysis.
Conclusions: the tested decoction, orally administered at one dose, is regarded as unclassified for the animal model and the dosage used under the observed experimental conditions.

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