medigraphic.com
ISSN 1025-0298 (Electronic)
ISSN 1025-028X (Print)

2011, Number 1

<< Back Next >>

VacciMonitor 2011; 20 (1)

Neuroimmunological response in children with meningoencephalitis by Neisseria meningitidis

Padilla-Docal B, Ferro-Blanco R, Dorta-Contreras AJ, Coifiu-Fanego RB, De Paula-Almeida OS, Martínez-Alderete R

Language: Spanish
References: 20
Page: 8-12
PDF size: 229.18 Kb.


ABSTRACT

Meningococcal disease is a clinical entity that remains as health world problem. It mostly affects children population producing gravity, a severe evolution, and a high quantity of deaths and sequels. Neisseria meningitidis is the etiological agent. The mucosa membranes of human nasopharynx are its natural habitat. This paper aims at establishing and determining the characteristics of the neuroimmunological response in children suffering from meningoencephalitis caused by Neiseria meningitidis. Twenty children with this diagnosis from 1998 and 2009 were studied. Cerebrospinal fluid lumbar puncture and blood extraction were performed. Samples were collected at the time of admission of the children to the hospital. IgA, IgG, IgM, C3c and albumin were quantified. A reibergram was done according to the data obtained in the quantification. Blood-cerebrospinal fluid barrier dysfunction was present in 6 of studied patients and there was intrathecal synthesis of major immunoglobulins and C3c in 65 and 95% respectively. The occurrence of intrathecal synthesis of at least 2 types of major immunoglobulins associated to C3c was demonstrated, which participate in the mechanisms involved in the immune response in this disease.


REFERENCES

  1. Daley AJ. Meningococcal disease. Aust Fam Physician 2003;32:597-601.

  2. Vázquez JA. Portadores de meningococo: un enigma a finales del siglo XX. Enferm Infecc Microbiol Clin 2000;18:352-5.

  3. Climent Y, Urwin R, Yero D, Martínez I, Martín A, Sotolongo F, et al. The genetic structure of Neisseria meningitidis populations in Cuba before and after the introduction of a serogroup BC vaccine. Infect Genet Evol 2010;10:546-54. .

  4. Holst J, Martín D, Arnold R, Huergo CC, Oster P, O’Hallahan J, et al. Properties and clinical performance of vaccines containing outer membrane vesicles from Neisseria meningitidis. Vaccine 2009;27 Suppl 2:B3-12. .

  5. Domínguez F, Menéndez J, Ochoa R. An effective serogroup B meningococcal vaccine. Vaccine 2006;24:7025-6.

  6. Sotolongo F, González N. VA-MENGOC-BC®, una década de experiencia. Avances Médicos de Cuba 1999;18:8-12.

  7. Sierra GV, Campa HC, Valcárcel NM, García IL, Izquierdo PL, Sotolongo PF et al. Vaccine against group B Neisseria meningitidis: Protection trial and mass vaccination in Cuba. NIPH Ann 1991;14:195-207.

  8. Dorta Contreras AJ, Noris García E, Bu-Coifiu Fanego R y Padilla Docal B. Bases moleculares de la Neuroinmunología (I). Barrera sangre-líquido cefalorraquídeo y síntesis intratecal de inmunoglobulinas. Rev Cubana Pediatr 2005;77(3). Disponible en: http://bvs.sld.cu/revistas/vol77: 3-4. 05/ ped03305.htm

  9. Dorta-Contreras AJ, Noris-García E, Bu-Coifiu Fanego R, Padilla-Docal B. Bases moleculares de la Neuroinmunología (II). El reibergrama y su uso en Neuroinmunología. Rev Cubana Pediatr 2005;77(3). Disponible en: http://www.bvs.sld.cu/ revistas/vol77:3-4. 05/ped04305.htm

  10. Dorta-Contreras AJ. Reibergramas: elemento esencial en el análisis inmunológico del líquido cefalorraquídeo. Rev Neurol 1999; 28:996-8.

  11. Dorta-Contreras AJ, Noris-García E, Reiber H. Reibergrama para la evaluación de la síntesis intratecal de IgE. Rev Neurol 2004;39:794-5.

  12. Dorta-Contreras AJ, Noris-García E, Padilla-Docal B, Rodríguez-Rey A, Bu-Coifiu Fanego R, Magraner-Tarrau ME, et al. Reibergrama para la evaluación de la síntesis intratecal de C3c. Arq Neuropsiquiatr 2006; 64 (3-A):585-8.

  13. Padilla-Docal B, Dorta-Contreras AJ, Bu-Coifiu-Fanego R, Rodríguez-Rey A. C4CSF/serum quotient graphs for the evaluation of intrathecal C4 synthesis Cerebrospinal Fluid. Research 2009, 6:8. Disponible en: http:// www.cerebrospinalfluidresearch. com/content/6/1/8.

  14. Sáfadi MA, Cintra OA. Epidemiology of meningococcal disease in Latin America: current situation and opportunities for prevention. Neurol Res. 2010 Apr;32(3):263-71.

  15. Reiber H. Flow rate of cerebrospinal fluid (CSF) –a concept common to normal blood- CSF barrier function and to dysfunction in neurological diseases. J Neurol Sci 1994;122:189-203.

  16. Dorta Contreras A J, Reiber H, Noris García E, Padilla Docal B, Bu Coifiu Fanego R, Pedroso Camejo F L, et al. Barrera Sangre- Líquido Cefalorraquídeo. Ciudad de la Habana; Editorial Academia; 2006.

  17. Dorta Contreras AJ, Nuñez N, Pérez O. Neuroinmunología de la meningoencefalitis por Neisseria meningitidis. En: Dorta Conteras AJ, Bu Coifiu Fanego R, Magraner Tarrau ME, Montoro Cardoso E, Nuñez Fernándes FA, Fundora Hernández H. Neuroinmunología Clínica. Ciudad de la Habana: Editorial Academia; 2009. p. 11-15.

  18. Bu Coifiu Fanego R, Dorta Contreras AJ, Ferrá Valdés M,Torres Romo U. Ruptura de la barrera hematoencefálica y síntesis intratecal de inmunoglobulinas II. Síntesis local de inmunoglobulinas. Rev Cubana Pediatr 1993; 65(2):94-103.

  19. Lejon, V, Robays J, N’Siesi FX, Mumba D, Hoogstoel A, Bisser S, et al. Treatment failure related to intrathecal immunoglobulin M (IgM) synthesis, cerebrospinal fluid IgM, and interleukin-10 in patients with hemolymphatic-stage sleeping sickness. Clin Vacc Immunol 2007;14:732–7.

  20. Padilla Docal B, Dorta Contreras AJ, Bu Coifiu Fanego R, Noris García E, Fundora Hernández H, Callol Barroso J, et al. Síntesis intratecal de C3c e inmunoglobulinas en niños con meningoencefalitis bacteriana .VacciMonitor 2008;17(3):1-5.




2020     |     www.medigraphic.com