2002, Number 3
<< Back Next >>
An Med Asoc Med Hosp ABC 2002; 47 (3)
Intralesional steroid injection in the management of benign esophageal stenosis not resolved with conventional dilatation
Fournier MFJ, González ARA, Robles DI, Noble LA, Cedillo LI, Mora LG, López AME, Rodríguez VG, Farca BA
Language: Spanish
References: 14
Page: 142-145
PDF size: 48.08 Kb.
ABSTRACT
Objective: To demonstrate the value of the intralesional steroid injection in the endoscopic management of benign esophageal strictures, not resolved by conventional dilation.
Material and Methods: In a prospective study, 15 patients with benign (endoscopic and histopathology) esophageal stricture, who have failed with conventional dilation (more than 4 dilations without relieve of dysphagia) were included. Dilation was performed with the conventional technique (Savary Gilliard boogies [3], endoscopic and fluoroscopic control) and the steroid (betametasone dipropionate 5.0 mg and betametasone disodic phosphate 2.0 mg) was injected intralesional. An endoscopic control was performed (7 days) with new dilation (if needed) and dysphagia was evaluated. The dilation index was calculated (number of dilations/time) with and without the intralesional steroid injection. The results were compared.
Results: Mean age of the 15 patients (11 men, 4 women) was 62 years (21-85). Twelve (80%) had peptic stricture, two (13.3%) secondary to caustic ingestion and one (6.66%) at the site of a surgical anastomosis. The difference when comparing the dilation index was statistically significative in 13 patients (86.6%). Only two patients (13.3%) required surgical treatment. There were no complications.
Conclusions: Intralesional steroid injection is a useful procedure as a therapeutic complement to the esophageal dilation in benign strictures not resolved with conventional dilation.
REFERENCES
Zargar SA, Kochbar R, Nagi B, Mehta SK. Ingestion of strong corrosive alkalis: spectrum of injury to upper gastrointestinal tract and natural history. Am J Gastroenterol 1992; 87: 337-344.
Holder TM, Aschcraft KW, Leape L. The treatment of patients with esophageal strictures by local steroid injections. J Pediatr Surg 1969; 4: 646-653.
Burdick JS, Hogan WJ, Massey BT, Bohorfoush AG, Parker H, Schmaiz M. Triamcinolone injections decrease the need for dilation of rapidly recurring esophageal strictures. Gastrointest Endosc 1994; 104: 907-915.
Russell SB, Trupin JS, Myers JC. Differential glucocorticoid regulation of collagen mRNAs in human dermal fibroblasts. J Biol Chem 1989; 264: 730-735.
Spain DM, Molomut N, Haber A. The effect of cortisone on the formation of granulation tissue on mice. Am J Pathol 1950; 26: 710-711.
Haller JA, Andrews HG, White JJ, Tamer MA, Cleveland WW. Pathophysiology and management of acute corrosive burns of the esophagus: results of treatment in 285 children. J Pediatr Surg 1971; 6: 578-584.
O’Neill JA, Betts J, Ziegler MM, Schnaufer L, Bishop HC, Templeton JM. Surgical management of reflux strictures of the esophagus in childhood. Ann Surg 1982; 196: 453-460.
Mendelsohn HJ, Maloney WH. The treatment of benign stricture of the esophagus with cortisone injection. Ann Otol Rhinol Laryngol 1970; 79: 900-904.
Gandhi RP, Cooper A, Barlow BA. Successful management of esophageal strictures with resection or replacement. J Pediatr Surg 1989; 24: 745-750.
Kirsch M, Blue M, Desai RK, Sivak MV. Intralesional steroid injections for peptic esophageal strictures. Gastrointest Endosc 1991; 37: 180-182.
Rupp T, Earle D, Hawes R et al. Randomized trial of Savary dilation with/without intralesional steroids for benign gastroesophageal reflux strictures. Gastrointest Endosc 1994; 40: 78.
Perrault J, Greseth JM, Zein NN. Endoscopic intralesional steroid injections in the management of refractory esophageal strictures. Gastrointest Endosc 1995; 41: 6, 596-597.
Lee M, Kubik CM, Polhamus CD, Brady CE, Kadakia SC. Preliminary experience with endoscopic intralesional steroid injection therapy for refractory upper gastrointestinal strictures. Gastrointest Endosc 1995; 41: 6, 598-601.
Lahoti D, Broor SL, Bassu PP, Gupta A, Sharma R, Pant CS. Corrosive esophageal strictures: Predictors of response to endoscopic dilation. Gastrointest Endosc 1995; 41: 3, 196-200.