Cervantes-Ruiz MA, Rivera-Rueda MA, Yescas-Buendía G, Villegas-Silva R, Hernández-Peláez G

Language: Spanish
References: 23
Page: 17-24
PDF size: 112.37 Kb.

ABSTRACT

Introduction: The intraventricular hemorrhage (IVH) is a complication of the preterm infants and the incidence is inversely related to gestational age and birth weight. The care and treatment of those babies with IVH has been changing over time. Objective: determine the factors associated in the development of IVH in the study group and also consider measures to reduce this pathology. Material and methods: A cross-sectional retrospective study was designed to assess premature infants with IVH, at the time of discharge from the neonatal therapy during 2009. Maternal and neonatal conditions were analyzed using descriptive statistics and factors associated with the severity of the IVH with odds ratio and (CI 95%). Results: The overall rate of IVH was 6.1%. Grade I occurred in 62%, grade II in 22%, grade III in 13% and grade IV, 3%. Birth weight less 1000 g (5.75, 1.35-24.49), Apgar score 4-6 at five minutes (22.71, 2.06-249.5) and necrotizing enterocolitis (8, 1.78-35.93), were associated with IVH grade III and IV. Conclusion: Preterm infants are of risk for developing intraventricular hemorrhage. In this study, birth weight less 1,000 g, low Apgar score and necrotizing enterocolitis were associated with IVH grade III and IV.

REFERENCES

1. Ballabh P. Intraventricular hemorrhage in premature infants: mechanism of disease. Pediatr Res 2010; 67: 1-8.

2. Inder TE, Volpe JJ. Mechanisms of perinatal brain injury. Semin Neonatol 2000; 5: 3-16.

3. Volpe JJ. Intracraneal hemorrhage: germinal matrix-intraventricular hemorrhage. In: Neurology of the Newborn, 4th ed. Philadelphia: WB Saunders; 2001: 428.

4. Bartels DB, Kreienbrock L, Dammann O, Wenzlaff P, Poets CF. Population based study on the outcome of small for gestational age newborns. Arch Dis Child Fetal Neonatal Ed 2005; 90: F53-9.

5. Fanaroff AA, Stoll BJ, Wright LL, Carlo WA, Ehrenkranz RA, Stark AR, Bauer CR, et al. Trends in neonatal morbidity and mortality for very low birth weight infants. Am J Obstet Gynecol 2007; 196: 147:e1-8.

6. Amato M, Konrad D, Hüppi P, Donati F. Impact of prematurity and intrauterine growth retardation on neonatal hemorrhagic and ischemic brain damage. Eur Neurol 1993; 33: 299-303.

7. Shaver DC, Bada HS, Korones SB, Anderson GD, Wong SP, Arheart KL. Early and late intraventricular hemorrhage: the role of obstetric factors. Obstet Gynecol 1992; 80: 831-7.

8. Shankaran S, Bauer CR, Bain R, Wright LL, Zachary J. Prenatal and perinatal risk and protective factors for neonatal intracranial hemorrhage. National Institute of Child Health and Human Development Neonatal Research Network. Arch Pediatr Adolesc Med 1996; 150: 491-7.

9. 9 Grant A, Glazener CM. Elective caesarean section versus expectant management for delivery of the small baby. The Cochrane Database of Systematic Reviews 2001; 2: CD000078. DOI: 10.1002/14651858.CD000078.

10. Paul DA, Sciscione A, Leef KH, Stefano JL. Caesarean delivery and outcome in very low birthweight infants. Aust N Z J Obstet Gynaecol 2002; 42: 41-5.

11. Deulofeut R, Sola A, Lee B, Buchter S, Rahman M, Rogido M. The impact of vaginal delivery in premature infants weighing less than 1,251 grams. Obstet Gynecol 2005; 105: 525.

12. Riskin A, Riskin-Mashiah S, Bader D, Kugelman A, Lerner-Geva L, Boyko V et al. Delivery mode and severe intraventricular hemorrhage in single, very low birth weight, vertex infants. Obstet Gynecol 2008; 112: 21-8.

13. Haque KN, Hayes AM, Ahmed Z, Wilde R, Fong CY. Caesarean or vaginal delivery for preterm very-low-birth weight (£ 1,250 g) infant: experience from a district general hospital in UK. Arch Gynecol Obstet 2008; 277: 207-12.

14. McCrea HJ, Ment LR. The diagnosis, management and prevention of intraventricular hemorrhage in the preterm neonate. Clin Perinatol 2008; 35: 777–vii. doi:10.1016/j.clp.2008.07.014.

15. Ferreyra M, D’Agustini M, Demarchi M, Emmerich J, Tornesello B, Aguado A et al. Hemorragia intraventricular-matriz germinal (HIV-MG) Nuestra experiencia. Rev Neur 2007; IX: 124-31.

16. Ayala-Mendoza AM, Carvajal-Kalil LF, Carrizosa-Moog J, Galindo-Hernández A, Cornejo-Ochoa JW, Sánchez-Hidalgo Y. Evaluación de la incidencia y los factores de riesgo para hemorragia intraventricular (HIV) en la cohorte de recién nacidos prematuros atendidos en la Unidad Neonatal del Hospital Universitario San Vicente de Paúl, de Medellín, en el periodo comprendido entre enero de 1999 y diciembre de 2004; Iatreia 2004(20): 341-53.

17. Barragán-Lee JR, Valenzuela-García L, Guerra-Tamez A, Rodríguez-Balderrama I. Factores de riesgo de hemorragia intraventricular en prematuros menores de 1,500 g en el Hospital Universitario Dr. José Eleuterio González, UANL. Medicina Universitaria 2005; 7: 116-22.

18. Calderón GJ, Vega MG, Velásquez TIJ, Morales CR, Vega-Malagón AJ. Factores de riesgo materno asociado al parto pretérmino. Rev Med IMSS 2005; 43: 339-42.

19. Villanueva-Egan LA, Contreras-Gutiérrez AK, Pichardo-Cuevas M, Rosales-Lucio J. Perfil epidemiológico del parto prematuro. Ginecol Obstet Mex 2008; 76: 542-8.

20. Lee BH, Stoll BJ, McDonald SA, Higgins RD, National Institute of Child Health and Human Development Neonatal Research Network. Adverse neonatal outcomes associated with antenatal dexamethasone versus antenatal betamethasone. Pediatrics 2006; 117: 1503-10.

21. Elimian A, Garry D, Figueroa R, Spitzer A, Wiencek V, Quirk JG. Antenatal betamethasone compared with dexamethasone (betacode trial): a randomized controlled trial. Obstet Gynecol 2007; 110: 26-30.

22. Soraisham AS, Singhal N, McMillan DD, Sauve RS, Lee SK. A multicenter study on the clinical outcome of chorioamnionitis in preterm infants. Am J Obstet Gynecol 2009; 200: 372.e1-6.

23. Fowlie PW, Davis PG, McGuire W. Prophylactic intravenous indomethacin for preventing mortality and morbidity in preterm infants. Cochrane Database of Systematic Reviews 2010;7. Art. No.: CD000174. DOI: 10.1002/14651858.CD000174.pub2.