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2012, Number 3

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Revista Habanera de Ciencias Médicas 2012; 11 (3)

Glucose cellular metabolism and ammoniagenesis in the kidney

Espinosa SI, Pérez MA, Pérez RA, Barber FMO

Language: Spanish
References: 23
Page:
PDF size: 126.84 Kb.


ABSTRACT

Introduction: The same as the liver, the kidney carries out complex metabolic activities, this is possible due to the presence in the same one of multiple complex enzymatic able to carry out all the necessary metabolic transformations. The kidneys intervene in the metabolism through several processes that happen in a different way in the different portions of the organ.
Methodology: with the objective of describing the particularities of the metabolism of the glucose and the amoniogénesis in the kidney logical-deductive, analytic and synthetic methods were used. taking like different investigators' scientific base, consulted in national and international, printed and electronic scientific magazines; these last ones obtained of specialized databases, as Scielo, PubMed and Hinari. The glycolysis is the metabolic but old road, it contributes the biggest quantity in energy dedicated mainly to transport of substances and to renal breathing. The renal glyconeogenesis acquires great importance in the states of alteration of the acid-base equilibrium where decrease liver metabolic efficiency. Glutamine is the main substrate of the renal glyconeogenesis, to the whose concentration in the renal tubular cells is bigger than the plasmatic one. This amino acid is the main contributer of the renal ammoniagenesis. The last constitutes the main mechanism of excretion of ammonia in the organism.
Conclusion: renal glucose metabolism has as result the adequate function of the tubular transport system.


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