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ISSN 2992-8559 (Electronic)
ISSN 1405-0625 (Print)

2002, Number 3

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Cir Plast 2002; 12 (3)

Dimethyl sulfoxide effect in capsule formation surrounding silicon implants in rats

Meza-Pérez A, Cortez GE

Language: Spanish
References: 28
Page: 94-99
PDF size: 112.12 Kb.


ABSTRACT

Mammary hardening due to capsule contracture surrounding silicon implants continues to be a frequent complication of augmentation mammaplasty. Several treatments have been used, but none has succeeded in eliminating the problem completely. Since dimethyl sulfoxide (DMSO) dissolves the pathological deposits of collagen, reduces the tensile strength and preserves the normal elastic fibers, this study was aimed at identifying the effect of this substance in the formation of the capsule, applying it around miniature silicon gel implants in experimental animals. The study included 18 laboratory rats in which two implants on the submuscular pocket of each dorsum were placed (36 total); in six DMSO was irrigated, in six triamcinolone and in six (the control group) no medicine was used. The biopsies in block of implants and adjacent tissues of the rats given DMSO, at 30, 45 and 60 days, in comparison with the control group, showed a meaningful decrease in the thickness of the capsule, minimal fibroblastic formation of uniform and lineal collagen fibers, as well as scarce inflammatory response, concluding that DMSO in the experimental animal is useful in reducing the formation of the capsule surrounding the implant and that if this is even minimally formed the collagen fibers, are uniform and lineal.


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