Morales MVMI

Language: Spanish
References: 19
Page: 125-130
PDF size: 38.46 Kb.

ABSTRACT

A bibliographic research was performed in order to achieve many different primary works and secondary discussion surveys, as well as some reviews, dealing with metabolic syndrome and different laboratory parameters, mainly insulin resistance, hormonal relations and adipocitoquines. In particular, abount 100 Medline reference items were read and also resumed, in about one year survey. Because of the variability in the definition of the clinical entity, as a matter of fact some textbook were consulted to uniform and simplify the guidelines on pathophisiology of obesity y and problems associated. All the topics are intended to drive to the hypothesis that obesity per se is an independent variable, which predicts multiple co-morbidities. It results from conditions derived from postmodernist societies with an accelerated sedentary regimen overwhelming an “ancient” caloricsaving genome, pound by pound. This can explain the wide variety of changes conducting to morbidity and mortality in all demographic conditions:sex, race, age, food intake, habits, geography, cornorbidities, etc.

REFERENCES

1. Alberti, KG., Zimmet, P.Z. Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: Provisional report of a W.H.O. consultation. Diabet. Med. 1998 15: 539- 53.

2. Bonora E, Targher G, Formentini G, et al. The metabolic syndrome is an independent predictor of cardiovascular disease in type II diabetic subjects. Prospective data from the Verona Diabetes Complications Study. Diabetic Med. 2004; 21:52-58.

3. Bruns C, et al. Binding properties of somatostatin receptor subtypes. Metabolism 45:17-20, 1996.

4. Chen, G. et al. Disappearence of body fat in normal rats induced by adenovirus-mediated leptin gene therapy . Proc. Nat. Acad. Sci. USA 93: 14.804- 14.808, 1996.

5. Eilertson CD, Kitrilson JD and MA Sheridan. Effects of insulin, glucagon, and somatostatin on the release of somatostatin-25 and somatostatin-14 from rainbow trout, Oncorhyncus mykiss, pancreatic islets in Vitro. Gen Comp Endocrinol. 1995 Sep; 99 (2): 211-20.

6. Eckel RH. Obesity: mechanisms and clinical management. Philadelphia (PA). Lippincott Williams and Wilkins, 2003.

7. Erdman J, Lippl F, Wagenfeil S, Schusdziarra V. Differential association of basal and postprandial plasma ghrelin with leptin, insulin and type II diabetes. Diabetes 54:5: 1371-8 May 2005.

8. Haffner SM, Miettinen H. Insulin resistance implications for type II diabetes mellitus and coronary heart disease. Am. J. Med. 1997; 103: 152-162.

9. Holcomb IN, Kabakoff RC, Chan B, Baker TW, Gurney A, Henzel W, et al. “FIZZ1, a novel cystein rich secreted protein associated with pulmonary inflammation, defines a new gene family”. EMBO J. 2000; 19: 4046-4055.

10. Isomaa B, Almgren P, Tuomi T, et al. Cardiovascular morbidity and mortality associated with metabolic syndrome. Diabetes Care 2001; 24: 683- 89.

11. Kahn, C.R. The molecular mechanism of insulin action. Annu Rev. Med. 1985; 36: 429.

12. Kylin, E. Studien. Hipertonie-Hyperglycamie- Hyperurikamiesyndrome. Zentralblatt fur innere Medizine. Vol. 44, 1923.

13. Maahs, D.M.; Ogden, L.G.; Kinney, G.L. et al. Low plasma adiponectin levels predict progression of coronary artery calcification. Circulation 2005; 111:747-53), ( Matsuzawa, Y.; Funahashi, T.; Kihara, S.; Shimomura, I. Adiponectin and metabolic syndrome. Arterioscler Thromb Vasc Biol 2004; 24: 29-33.

14. Malik S, Wong, ND, Franklin, SS, et al. Impact of the metabolic syndrme on mortality from coronary heart disease, cardiovascular disease, and alI causes in the United States adults. Circulation 2004; 110: 1245- 1250.

15. Matsuda, Y., Tanaka, T., Inomata, N., y otros. Ghrelin stimulates gastric acid secretion and motility in rats. Biochem. Biophys. Res. Commun. 2000; 276: 905- 908 (Cross Ref. [isi] Medline.

16. Rea R, Donnelly R. Resistin: an adipocyte- derived hormone. Has it a rol in diabetes and obesity? Diabetes Obes Metab 2004; 6: 163- 470 [Cross ref Med Line, Infotrieve].

17. Vague, J. La differenciation sexuelle, facteur determinant des formes de l’obesitè. Press med. 1947; 30: 339-40.

18. Wei, J.N.; Sung, F.C.; Lin, C.C.: Chuang, L.M. National surveillance for type 2 diabetes mellitus in taiwanese children. JAMA 2003; 290: 1345-50.

19. World Health Organization, Western Pacific Region. The Asia Pacific Perspective. Redefining Obesity and its treatment. WHO/IASO/IOTF, 2000.