Cota GH

Language: Spanish
References: 13
Page: 95-98
PDF size: 155.14 Kb.

ABSTRACT

The present review article centers its attention in obstructive sleep apnea/hypopnea syndrome and its consequences in cognitive functions and posterior changes in these functions after treatment with CPAP therapy. Obstructive sleep apnea/hypopnea syndrome is a disorder characterized by an obstruction in the upper respiratory airway during sleep even with an adequate ventilator effort. This obstruction provokes a series of symptoms including fragmented sleep, deterioration in cognitive execution with deficits in short term memory, verbal training, perception, thinking and communication. Nowadays, continuous positive airway pressure (CPAP) is the most used treatment of this sleep disorder. Diverse studies have evaluated the efficacy of treatment in the symptoms of obstructive sleep apnea/hypopnea syndrome although the results are not conclusive, in other words, cases have been identified in which patients improved significantly in some cognitive functions, while in others, these improvements were not observed in spite of the decreased levels of daytime somnolence.

REFERENCES

1. Young T, Palta M, Dempsey J, Skatrud J, et al. The occurrence of sleep-disordered breathing among middle-aged adults. N Engl J Med 1993;328(17):1230-1235.

2. Chervin RD, Pickett R, Guilleminault C. Comparison of Epworth Sleepiness Scale and Multiple Sleep Latency Test results. Sleep Research 1995;24:466.

3. Sher AE, Schechtman KB, Piccirillo JF. The efficacy of surgical modifications of the upper airway in adults with obstructive sleep apnea syndrome. Sleep 1996;19(2):156-177.

4. Loube DI, Gay PC, Strohl KP, Pack AI, et al. Indications for positive airway pressure treatment of adult obstructive sleep apnea patients: a consensus statement. Chest 1999;115(3):863-866.

5. Findley L, Unverzagt M, Guchu R, Fabrizio M, et al. Vigilance and automobile accidents in patients with sleep apnea or narcolepsy. Chest 1995;108(3):619-624.

6. Findley LJ, Barth JT, Powers DC, Wilhoit SC, et al. Cognitive impairment in patients with obstructive sleep apnea and associated hypoxemia. Chest 1986;90(5):686-690.

7. Cross RL, Kumar R, Macey PM, Doering LV, et al. Neural alterations and depressive symptoms in obstructive sleep apnea patients. Sleep 2008;31(8):1103-1109.

8. Ayalon L, Ancoli-Israel S, Drummond SP. Altered brain activation during response inhibition in obstructive sleep apnea. J Sleep Res 2009;18(2):204-208.

9. Archbold KH, Borghesani PR, Mahurin RK, Kapur VK, Landis CA. Neural activation patterns during working memory tasks and OSA disease severity: preliminary findings. J Clin Sleep Med 2009;5(1):21-27.

10. Lim W, Bardwell WA, Loredo JS, Kim EJ, et al. Neuropsychological effects of 2-week continuous positive airway pressure treatment and supplemental oxygen in patients with obstructive sleep apnea: a randomized placebocontrolled study. J Clin Sleep Med 2007;3(4):380-386.

11. Sánchez AI, Bermúdez MP, Buela-Casal G. Evaluación de la memoria a corto plazo en pacientes con apnea del sueño antes y después del tratamiento con CPAP. Salud Mental 2003;26(6):55-61.

12. Felver-Gant JC, Bruce AS, Zimmerman M, Sweet LH, et al. Working memory in obstructive sleep apnea: construct validity and treatment effects. J Clin Sleep Med 2007;3(6):589-594.

13. Bardwell WA, Ancoli-Israel S, Berry CC, Dimsdale JE. Neuropsychological effects of one-week continuous positive airway pressure treatment in patients with obstructive sleep apnea: a placebo-controlled study. Psychosom Med 2001;63(4):579-584.