medigraphic.com
ISSN 1561-3054 (Electronic)

2012, Number 1

<< Back Next >>

Rev Cubana Med Trop 2012; 64 (1)

Epidemiological analysis of eosinophilia and elevation of immunoglobulin E as a predictable and relative risk of enteroparasitosis

Vieira SCC, Nogueira FRR, Fornari JV, Sena BA

Language: English
References: 18
Page: 22-26
PDF size: 74.71 Kb.


ABSTRACT

Introduction: among the intestinal parasites, the helminthiasis occupies a prominent position in Brazil, since it worsens malnutrition and the gives rise to neurovegetative disorders. Helminths like Ascaris lumbricoides, Enterobius vermicularis, hookworm, Trichuris trichiura and Strongyloides stercoralis stand out due to several factors that modulate the immune response of individuals. Among the protozoa are Giardia lamblia, Entamoeba histolytica/E. dispar. Parasitic helminth antigens are important to stimulate the production of cytokines such as interleukin-4 and interleukin-5, which act through the induction of IgE synthesis and activation of eosinophils. Eosinophilia is usually detectable in pre-patent period of parasitism, initially linked to B lymphocytes, under the command of Th-2 lymphokines (IL-4 and IL-5), producing IgE in response to initial exposure to an antigen or allergen. Serum IgE high levels occur in tissue migration of larvae or harboring of parasites in tissues. Objective: to determine the presence of eosinophils and IgE elevation in children with intestinal parasites. Methods: high levels of IgE and eosinophils were observed in groups infected and not infected (allergic) to calculate the relative risk of intestinal parasites presumptive differentiated between protozoa and helminths and check what values of these indicators are observed in the epidemiological profile of the surveyed population. Results: the values obtained by calculating the relative risk for eosinophilia, compared with helminths and allergies was 11.71, but when examined by giardiasis compared with other diseases, the relative risk was 0.75. Since the comparison of helminths and giradiase, the relative risk was 27.33. Since IgE and its parameters were appropriate commit Helminth relative risk 0.39; Giardiasis had relative risk 8, 18 and Helminths compared with giardiasis had 0.03. Conclusion: in this study it was possible to observe that helminthiasis is connected with cases of eosinophilia with alteration of IgE, which in turn contributes to the presence of IgE eosionofilia and has an effector response against helminths that provides the expulsion of its larvae.


REFERENCES

  1. Ludwig KM, Frei F, Álvares Filho F, Ribeiro Paes JT. Correlação entre condições de saneamento básico e parasitoses intestinais na população de Assis, Estado de São Paulo. Rev Soc Bras Med Trop. 1999;32(5):547-55.

  2. Ferreira CB, Marçal Junior O. Enteroparasitoses em escolares do Distrito de Martinésia, Uberlândia, MG: um estudo piloto. Rev Soc Bras Med Trop. 1997;30(5):373-77.

  3. Biscegli TS, Romeia J, Candido AC, Santos JM, Candido ECA, Binottro AL. Estado nutricional e prevalência de enteroparasitoses em crianças matriculadas em creches. Rev Paulista Pediatri. 2009;27(3):289-95.

  4. Ferreira MU, Ferreira CS, Monteiro CA. Tendência secular de parasitoses intestinais na infância na cidade de São Paulo (1984-1996). Rev Saude Pública. 2000;34(6):73-82.

  5. Fontes G, Oliveira KKL, Oliveira AKL, Rocha EMM. Influência do tratamento específico na prevalência de enteroparasitoses e esquistossomose mansônica em escolares do município de Barra de Santo Antônio, AL. Rev Soc Bras Med Trop. 2003;36(1):625-8.

  6. Machado RLD, Figueiredo MC, Frade AF, Kudo MD, Sila Filho MG, Póvoa MM. Comparação de quatro métodos laboratoriais para diagnóstico da Giardia lamblia em fezes de crianças residentes em Belém, Pará. Rev Soc Bras Med Trop. 2001;34(1):91-3.

  7. Melo-Reis MPR. Correlação entre eosinofilia e protoparasitose por Giardia lamblia em crianças. Rev Bras Anal Clin. 2007;39(3):237-9.

  8. Medeiros D, Silva AR, Rizzo JA, Motta ME, de Oliveira FHB, Sarinho ESC. Nível sérico de IgE total em alergia respiratória: estudo em pacientes com alto risco de infecção por helmintos. J Pediatri. 2006;82(4):255-9.

  9. Machado PRL, Arruda KL, Rodrigues MAG, Araujo MME, Sales VSP. Mecanismo de Resposta Imune. Educ Medic Continuada. 2004;40(6):289-90.

  10. Fontenele ALA, Carvalho PG, Ferreira CHA, Girão AB, Teixeira MJ, Queiroz JAN. Avaliação da dosagem de interleucina-5 e imunoglobulina E em pacientes com giardíase com ou sem eosinofilia. Rev Bras Anal Clin. 2006;38(3):201-6.

  11. Rosário NA, Carneiro MF, Ferreira E, Baranski MC. Níveis de IgE total no soro, eosinófilos em crianças com enteroparasitoses: efeito do tratamento anti-helmíntico. J Pediatri. 2007;52(4):209-15.

  12. Hoffman W, Pons JL, Janer JL. The sedimentationconcentration methods in Schistosoma mansoni. Puerto Rico. J Pub Health. 1934;9:283-91.

  13. Vallada EP. Manual de exames de Fezes Coprologia e Parasitologia. Rio de Janeiro: Atheneu; 1988. p. 201.

  14. Zago MA. Hematologia: Fundamentos e Prática. São Paulo: Atheneu; 2004. p. 1081.

  15. Soares JLM. Métodos Diagnósticos. Rio de Janeiro: Artmed; 2002. p. 560.

  16. Pereira MG. Epidemiologia-Teoria e Prática. 11. ed. Rio de Janeiro: Guanabara Koogan; 2007. p. 596.

  17. Gleich GJ. The eosinophils and bronchial astma: current understanging. J Allergeny Clin Immunol. 1990;85(2):422-33.

  18. Moqbel R. Exocytotic events in eosinophils and mast cells. Clin Exp Allergy. 1999;29(10):1017-22.




2020     |     www.medigraphic.com