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2008, Number 6

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Rev Med Inst Mex Seguro Soc 2008; 46 (6)

Procalcitonin a Marker in the Diagnostic of the Newborn with Systemic Infection

Ramírez-Valdivia JM, Pérez-Molina JJ, Locheo-González M, Troyo-Sanromán R, Pérez-Cortez G

Language: Spanish
References: 24
Page: 597-602
PDF size: 96.75 Kb.


ABSTRACT

Background: laboratory test used in the diagnosis of neonatal sepsis have a low specificity. Recently, procalcitonin has been proposed as a marker to identify the presence of systemic infections. The objective of the study was to evaluate the sensibility and specificity of procalcitonin as a marker of systemic infection in newborn with a suspicion of neonatal sepsis using a blood culture as a gold standard.
Methods: 21 newborn with a suspicion of neonatal sepsis were included in the study, postnatal age 8.3 ± 5.2 days in a period from October 2003 to a January 2004. Procalcitonin, were measured at the moment of clinical diagnosis and after 24 and 48 hours and twice blood culture were done.
Results: seven blood cultures were positive at the moment of diagnosis as well as 21 determinations of procalcitonin, sensibility 85.7 %, specificity 21.7 %; (OR = 1.63, 95 % CI = 0.14-19.4); determinations after 24 hours showed procalcitonin sensibility and specificity of 85.7 % and 28.5 % (OR = 2.4, 95 % CI = 0.22-26.6) and after 48 hours 100 % of sensibility and 42.8 % of specificity (OR = 1.75, 95 % CI = 1.11-2.75]).
Conclusions: positive procalcitonin has a good sensibility and moderate specificity 48 hours after clinical diagnosis of neonatal sepsis.


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