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2012, Number 3

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Rev Fac Med UNAM 2012; 55 (3)

Pre-clinical research at UNAM using microPET

Alva-Sánchez H, Rodríguez-Balderas CA, Trejo-Ballado F, Lara-Camacho V, Ávila-Rodríguez MÁ, Robles-Díaz G

Language: Spanish
References: 16
Page: 4-10
PDF size: 260.29 Kb.


ABSTRACT

Positron emission tomography (PET) is a nuclear medicine imaging technique well established in Mexico, essential for the clinical diagnosis and follow-up of oncological, neurological and cardiac pathologies. This molecular imaging modality is based on the administration of small amounts of drugs labeled with a positron emitting radionuclides and the subsequent radiation detection to obtain tomographic images which reflect the distribution of the radiopharmaceutical in the patient. The development of new radiopharmaceuticals for PET requires a method to verify that they follow the expected metabolic pathways, that they have a long-enough biological half-life for imaging studies, that they have no side effects and that it is viable for use in patients. The development of positron emission microtomography (microPET) systems to be used in small laboratory animale has allowed researchers to perform these tests on radiopharmaceuticals before being used in the clinic. In addition, microPET is a useful tool in preclinical research of different diseases in the development of innovating non-invasive treatments allowing to follow up animal models. At the PET/CT-Ciclotron Unit, Facultad de Medicina, UNAM, a microPET system has been available in the last few years for research purposes. In this work, examples of frequent imaging studies performed with the micro-PET and in-the-clinic commonly-used radiopharmaceuticals, as well the use it may have in different research projects are shown here.


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