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2009, Number 6

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Gac Med Mex 2009; 145 (6)

Coxib: una alternativa terapéutica factible en pacientes con intolerancia o hipersensibilidad al ácido acetilsalicílico, antiinflamatorios no esteroideos y paracetamol

Ramos-Bello D, Ramos-Niembro F

Language: Spanish
References: 201
Page: 505-515
PDF size: 108.56 Kb.


ABSTRACT

Aspirin, non-steroidal anti-inflammatory drugs (NSAIDs) and paracetamol are the most frequent drugs used worldwide for the management of pain, inflammation and fever associated with many acute and chronic conditions. Despite of its analgesic, antiinflammatory and antipyretic properties, all display adverse effects mediated by the same mechanisms by which they control pain, inflammation and fever. A relatively frequent problem with the use of NSAIDs and/or aspirin, and less frequently with paracetamol, is the development of intolerance and hypersensitivity reactions, a situation for which diverse alternatives have been proposed. One of theses includes the use cyclo-oxigenase-2 specific inhibitors (COXIB), a therapeutic modality analyzed in the present paper.


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