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Boletín Médico del Hospital Infantil de México

2011, Number 3

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Bol Med Hosp Infant Mex 2011; 68 (3)

Relationship among obesity, asthma and pulmonary function

del Río NBE, Eslava AB, Sienra MJJL

Language: Spanish
References: 102
Page: 171-183
PDF size: 496.52 Kb.


ABSTRACT

Obesity and asthma are public health issues. Many studies have demonstrated a relation between both conditions. There is a positive correlation between body mass index and asthma; the risk of suffering from asthma is greater as body mass increases. The probability for developing asthma in an obese school-age child may be as high as 50%. An association between obesity and asthma has been described more frequently in females, particularly in adult surveys. Obesity may directly affect asthma phenotype by mechanical effects in the respiratory tract, gastroesophageal reflux, production of proinflammatory cytokines in fat tissue (interleukin 6, tumor necrosis factor, leptin, adiponectin), activation of common genes, or by increased estrogen production. Obesity may worsen asthma symptoms as well as causing poor control of the condition. Weight loss improves symptomatology and pulmonary function, along with reducing the use of antiasthmatic medication. Therefore, it is necessary that management of obese asthmatic patients includes a weight control program.


REFERENCES

  1. Waggoner D, Stokes J, Casale TB. Asthma and obesity. Ann Allergy Asthma Immunol 2008;101:641-643.

  2. Wang Y, Lobstein T. Worldwide trends in childhood overweight and obesity. Int J Pediatr Obes 2006;1:11-25.

  3. Pereira MA. Obesity epidemiology. JAMA 2009;301:2274- 2275.

  4. Rivera-Dommarco J, Cuevas-Nasu L, Shamah-Levy T, Villalpando-Hernandez S, Ávila-Arcos MA, Jiménez-Aguilar A. Estado Nutricio. En: Olaiz-Fernández G, Rivera-Dommarco J, Shamah-Levy T, Rojas R, Villalpando-Hernández S, Sepúlveda J (eds). Encuesta Nacional de Salud y Nutrición 2006. Cuernavaca, México: Instituto Nacional de Salud Pública; 2006. pp. 83-121.

  5. Organización Mundial de la Salud. Obesidad y sobrepeso. Disponible en: http://www.who.int/mediacentre/factsheets/ fs311/es/index.html

  6. World Health Organization. Obesity: preventing and managing the global epidemic. WHO Technical Report Series 894. Geneva (Switzerland): WHO; 2000. Disponible en: http://whqlibdoc. who.int/trs/who_trs_894.pdf

  7. Barlow SE, Expert Committe. Expert committe recommendations regarding the prevention, assessment and treatment of child and adolescent overweight and obesity: summary report. Pediatrics 2007;120(suppl 4):S164-S192.

  8. Wyllie R. Obesity in childhood: an overview. Curr Opin Pediatr 2005;17:632-635.

  9. Cole TJ, Bellizzi MC, Flegal KM, Dietz WH. Establishing a standard definition for child overweight and obesity worldwide: international survey. BMJ 2000;320:1240-1243.

  10. Del Río-Navarro BE, Velázquez-Monroy O, Sánchez-Castillo C, Lara-Esqueda A, Berber A, Fanghänel G, et al. The high prevalence of overweight and obesity in Mexican children. Obes Res 2004;12:215-223.

  11. Freedman DS, Mei ZG, Srinivasan SR, Berenson GS, Dietz WH. Cardiovascular risk factors and excess adiposity among overweight children and adolescents: the Bogalusa Heart Study. J Pediatr 2007;150:12-17.e2.

  12. Reilly JJ, Methven E, McDowell ZC, Hacking B, Alexander D, Stewart L, et al. Health consequences of obesity. Arch Dis Child 2003;88;748-752.

  13. Freedman DS, Dietz WH, Srinivasan SR, Berenson GS. The relation of overweight to cardiovascular risk factors among children and adolescents: the Bogalusa Heart Study. Pediatrics 1999;103:1175-1182.

  14. Centers for Disease Control and Prevention. CDC Growth Charts. Atlanta: Department of Health and Human Services, National Center for Health Statistics; 2000. Report no. 314.

  15. Han TS, Williams K, Sattar N, Hunt KJ, Lean ME, Haffner SM. Analysis of obesity and hyperinsulinemia in the development of metabolic syndrome: San Antonio Heart Study. Obes Res 2002;10:923-931.

  16. Greco AV, Mingrone G, Giancaterini A, Manco M, Morroni M, Cinti A, et al. Insulin resistance in morbid obesity: reversal with intramyocellular fat depletion. Diabetes 2002;51:144-151.

  17. NAEPP, NHLBI, NIH. Expert Panel Report 3: Guidelines for the Diagnosis and Management of Asthma. USA: US Department of Health and Human Services; 2007.

  18. Del Río-Navarro B, Del Río-Chivardi JM, Berber A, Sienra- Monge JJL, Rosas-Vargas MA, Baeza-Bacab M. Asthma prevalence in children living in north Mexico City and a comparison with other Latin American cities and world regions. Allergy Asthma Proc 2006;27:334-340.

  19. Mallol J, Solé D, Baeza-Bacab M, Aguirre-Camposano V, Soto-Quiros M, Baena-Cagnani C, Latin American ISAAC Group. Regional variation in asthma symptom prevalence in Latin American children. J Asthma 2010;47:644-650.

  20. Fernandez Camilo D, Dirceu Ribeiro J, Dalbo Contrera Toro A, Elias Baracat EC, Barrio Filho A. Obesity and asthma: association or coincidence? J Pediatr (Rio J) 2010;86:6-14

  21. Castro-Rodríguez JA. Relación entre obesidad y asma. Arch Bronconeumol 2007;43:171-175.

  22. Ford ES. The epidemiology of obesity and asthma. J Allergy Clin Immunol 2005;115:897-909.

  23. Young SY, Gunzenhauser JD, Malone KE, McTiernan A. Body mass index and asthma in the military population of the northwestern United States. Arch Intern Med 2001;161:1605-1611.

  24. Camargo CA Jr, Weiss ST, Zhang S, Willett WC, Speizer FE. Prospective study of body mass index, weight change, and risk of adult-onset asthma in women. Arch Intern Med 1999;159:2582-2588.

  25. Gilmore J. Body mass index and health. Health Rep 1999;11:31-43.

  26. Schachter LM, Salome C, Peat J, Woolcock A. Obesity is a risk for asthma and wheeze but not airway hyperresponsiveness. Thorax 2001;56:4-8.

  27. Celedón JC, Palmer LJ, Litonjua AA, Weiss ST, Wang B, Fang Z, et al. Body mass index and asthma in adults in families of subjects with asthma in Anqing, China. Am J Respir Crit Care Med 2001;164:1835-1840.

  28. Beckett WS, Jacobs DR Jr, Yu X, Iribarren C, Williams OD. Asthma is associated with weight gain in females but not males, independent of physical activity. Am J Respir Crit Care Med 2001;164:2045-2050.

  29. Von Behren J, Kreutzer R, Hernandez A. Self-reported asthma prevalence in adults in California. J Asthma 2002;39:429-440.

  30. Xu B, Pekkanen J, Laitinen J, Järvelin MR. Body build from birth to adulthood and risk of asthma. Eur J Public Health 2002;12:166-170.

  31. Del-Rio-Navarro BE, Fanghänel G, Berber A, Sánchez-Reyes L, Estrada-Reyes E, Sienra-Monge JJL. The relationship between asthma symptoms and anthropometric markers of overweight in a Hispanic population. J Investig Allergol Clin Immunol 2003;13:118-123.

  32. Arif AA, Delclos GL, Lee ES, Tortolero SR, Whitehead LW. Prevalence and risk factors of asthma and wheezing among US adults: an analysis of the NHANES III data. Eur Respir J 2003;21:827-833.

  33. Pérez-Perdomo R, Pérez-Cardona C, Disdier-Flores O, Citrón Y. Prevalence and correlates of asthma in the Puerto Rican population: Behavioral Risk Factor Surveillance System, 2000. J Asthma 2003;40:465-474.

  34. Kim S, Camargo CA Jr. Sex-race differences in the relationship between obesity and asthma: the Behavioral Risk Factor Surveillance System, 2000. Ann Epidemiol 2003;13:666-673.

  35. Santillan AA, Camargo CA. Body mass index and asthma among Mexican adults: the effect of using self-reported vs. measured weight and height. Int J Obes Relat Metab Disord 2003;27:1430-1433.

  36. Luder E, Ehrlich RI, Lou WY, Melnik TA, Kattan M. Body mass index and the risk of asthma in adults. Respir Med 2004;98:29- 37.

  37. Mishra V. Effect of obesity on asthma among adult Indian women. Int J Obes Relat Metab Disord 2004;28:1048-1058.

  38. Shaheen SO, Sterne JA, Montgomery SM, Azima H. Birth weight, body mass index and asthma in young adults. Thorax 1999;54:396-402.

  39. Chen Y, Dales R, Tang M, Krewski D. Obesity may increase the incidence of asthma in women but not in men: longitudinal observations from the Canadian National Population Health Surveys. Am J Epidemiol 2002;155:191-197.

  40. Ford ES, Mannino DM, Redd SC, Mokdad AH, Mott JA. Body mass index and asthma incidence among USA adults. Eur Respir J 2004;24:740-744.

  41. Gunnbjörnsdottir MI, Omenaas E, Gíslason T, Norrman E, Olin AC, Jõgi R, et al. Obesity and nocturnal gastro-oesophageal reflux are related to onset of asthma and respiratory symptoms. Eur Respir J 2004;24:116-121.

  42. Huovinen E, Kaprio J, Koskenvuo M. Factors associated to lifestyle and risk of adult onset asthma. Respir Med 2003;97:273-280.

  43. Brisbon N, Plumb J, Brawer P, Paxman D. The asthma and obesity epidemics: the role played by the built environment — a public health perspective. J Allergy Clin Immunol 2005;115:1024-1028.

  44. Hasler G, Gergen PJ, Ajdacic V, Gamma A, Eich D, Rössler W, et al. Asthma and body weight change: a 20-year prospective community study of young adults. Int J Obes (Lond) 2006;30:1111-1118.

  45. McLachlan CR, Poulton R, Car G, Cowan J, Filsell S, Greene JM, et al. Adiposity, asthma, and airway inflammation. J Allergy Clin Immunol 2007;119:634-639.

  46. Beuther D, Sutherland R. Overweight, obesity, and incident asthma: a meta-analysis of prospective epidemiologic studies. Am J Respir Crit Care Med 2007;175:661-666.

  47. Gold DR, Damokosh AI, Dockery DW, Berkey CS. Body-mass index as a predictor of incident asthma in a prospective cohort of children. Pediatr Pulmonol 2003;36:514-521.

  48. Gilliland FD, Berhane K, Islam T, McConnell R, Gauderman WJ, Gilliland SS, et al. Obesity and the risk of newly diagnosed asthma in school-age children. Am J Epidemiol 2003;158:406- 415.

  49. Mannino DM, Mott J, Ferdinands JM, Camargo CA, Friedman M, Greves HM, et al. Boys with high body masses have an increased risk of developing asthma: findings from the National Longitudinal Survey of Youth (NLSY). Int J Obes (Lond) 2006;30:6-13.

  50. Flaherman V, Rutherford GW. A meta-analysis of the effect of high weight on asthma. Arch Dis Child 2006;91:334-339.

  51. Brenner JS, Kelly CS, Wenger AD, Brich SM, Morrow AL. Asthma and obesity in adolescents: is there an association? J Asthma 2001;38:509-515.

  52. Chinn S, Rona RJ. Can the increase in body mass index explain the rising trend in asthma in children? Thorax 2001;56:845-850.

  53. Guerra S, Sherrill DL, Bobadilla A, Martinez FD, Barbee RA. The relation of body mass index to asthma, chronic bronchitis, and emphysema. Chest 2002;122:1256-1263.

  54. Godfrey KM, Barker DPJ. Fetal nutrition and adult disease. Am J Clin Nutr 2000;71(suppl 5):1344S-1352S.

  55. Oken E, Gillman MW. Fetal origins of obesity. Obes Res 2003;11:496-506.

  56. Luder E, Melnik TA, DiMaio M. Association of being overweight with greater asthma symptoms in inner city black and Hispanic children. J Pediatr 1998;132:699-703.

  57. Eneli IU, Skybo T, Camargo CA Jr. Weight loss and asthma: a systematic review. Thorax 2008;63:671-676.

  58. Stenius-Aarniala B, Poussa T, Kvarnström J, Grönlund EL, Ylikahri M, Mustajoki P. Immediate and long term effects of weight reduction in obese people with asthma: randomised controlled study. BMJ 2000;320:827-832.

  59. Sin DD, Jones RL, Man SF. Obesity is a risk factor for dyspnea but not for airflow obstruction. Arch Intern Med 2002;162:1477-1481.

  60. Salome CM, King GG, Berend Norbert. Physiology of obesity and effects on lung function. J Appl Physiol 2010;108:206-211.

  61. Chlif M, Keochkerian D, Mourlhon C, Choquet D, Ahmadi S. Non-invasive assessment of the tension-time index of inspiratory muscles at rest in obese male subjects. Int J Obs (Lond) 2005;29:1478-1483.

  62. Jones RL, Nzekwu MM. The effects of body mass index on lung volumes. Chest 2006;130:827-833.

  63. Watson RA, Pride NB. Postural changes in lung volumes and respiratory resistance in subjects with obesity. J Appl Physiol 2005;98:512-517.

  64. Thomas PS, Cowen ER, Hulands G, Milledge JS. Respiratory function in the morbidly obese before and after weight loss. Thorax 1989;44:382-386.

  65. Schachter LM, Peat JK, Salome CM. Asthma and atopy in overweight children. Thorax 2003;58:1031-1035.

  66. Parameswaran K, Todd DC, Soth M. Altered respiratory physiology in obesity. Can Respir J 2006;13:203-210.

  67. Biring M, Lewis M, Liu JT, Mohsenifar Z. Pulmonary physiologic changes of morbid obesity. Am J Med Sci 1999;318:293-297.

  68. Tantisira KG, Weiss ST. Complex interactions in complex traits: obesity and asthma. Thorax 2001;56(suppl 2):64-73.

  69. Verhulst SL, Aerts L, Jacobs S, Schrauwen N; Haentjens D, Claes R, et al. Sleep-disordered breathing, obesity, and airway inflammation in children and adolescents. Chest 2008;134:1169-1175.

  70. Fredberg JJ, Inouye DS, Mijailovich SM, Butler JP. Perturbed equilibrium of myosin binding in airway smooth muscle and its implications in bronchospasm. Am J Resp Crit Care Med 1999;159:959-967.

  71. Kaplan Ta, Montana E. Exercise-induced bronchospasm in non astmathic obese children. Clin Pediatr (Phila) 1993;32:220- 225.

  72. Gennuso J, Epstein LH, Paluch RA, Cerny F. The relationship between asthma and obesity in urban minority children and adolescents. Arch Pediatr Adolesc Med 1998;152:1197- 1200.

  73. Chinn S, Jarvis D, Burney P, European Community Respiratory Health Survey. Relation of bronchial responsiveness to body mass index in the ECRHS. Thorax 2002;57;1028-1033.

  74. Litonjua AA, Sparrow D, Celedón JC, DeMolles D, Weiss ST. Association of body mass index with the development of methacholine airway hyperresponsiveness in men: the Normative Aging Study. Thorax 2002;57:581-585.

  75. Del Rio-Navarro B, Cisneros-Rivero M, Berber-Eslava A, Espínola-Reyna G, Sienra-Monge J. Exercise induced bronchospasm in asthmatic and non- asthmatic obese children. Allergol Immunopathol (Madr) 2000;28:5-11.

  76. Beuther DA, Sutherland ER. Obesity and pulmonary function testing. J Allergy Clin Immunol 2005;115:1100-1101.

  77. Jacobson BC, Somers SC, Fuchs CS, Kelly CP, Camargo CA Jr. Body-mass index and symptoms of gastroesophageal reflux in women. N Engl J Med 2006;354:2340-2348.

  78. Verhulst SL, Schrauwe N, Haentjens D, Suys B, Rooman RP, Van Gaal L, et al. Sleep-disordered breathing in overweight and obese children and adolescents: prevalence, characteristics and the role of fat distribution. Arch Dis Child 2007;92:205-208.

  79. Kohler MJ, van den Heuvel CJ. Is there a clear link between overweight/obesity and sleep disordered breathing in children? Sleep Med Rev 2008;12:347-361.

  80. Hakala K, Stenius-Aarniala B, Sovijärvi A. Effects of weight loss on peak flow variability, airways obstruction, and lung volumes in obese patients with asthma. Chest 2000;118:1315-1321.

  81. Aaron SD, Fergusson D, Dent R, Chen Y, Vandemheen KL, Dales RE. Effect of weight reduction on respiratory function and airway reactivity in obese women. Chest 2004;125:2046- 2052.

  82. Kwong KY, Rhandhawa I, Saxena J, Morphew T, Jones CA. Ability to control persistent asthma in obese versus non-obese children enrolled in an asthma-specific disease management program (breathmobile). J Asthma 2006;43:661-666.

  83. Vargas PA, Perry TT, Robles E, Jo CH, Simpson PM, Magee JM, et al. Relationship of body mass index with asthma indicators in head start children. Ann Allergy Asthma Immunol 2007;99:22-28.

  84. Carroll CL, Bhandari A, Zucker AR, Schramm CM. Childhood obesity increases duration of therapy during severe asthma exacerbations. Pediatr Crit Care Med 2006;7:527-531.

  85. Schaub B, von Mutius E. Obesity and asthma, what are the links? Curr Opin Allergy Clin Immunol 2005;5:185-193.

  86. Castro-Rodríguez JA, Holberg CJ, Morgan WJ, Wright AL, Martínez FD. Increased incidence of asthma-like symptoms in girls who become overweight or obese during the school years. Am J Respir Crit Care Med 2001;163:1344-1349.

  87. Cooper C, Kuh D, Egger P, Wadsworth M, Barker D. Childhood growth and age at menarche. Br J Obstet Gynecol 1996;103:814-817.

  88. Kaplowitz P. Delayed puberty in obese boys: comparison with constitutional delayed puberty and response to testosterone therapy. J Pediatr 1998;133:745-749.

  89. Romieu I, Varraso R, Avenel V, Leynaert B, Kauffmann F, Clavel-Chapelon F. Fruit and vegetable intakes and asthma in the E3N study. Thorax 2006;61:209-215.

  90. Nagel G, Linseisen J. Dietary intake of fatty acids, antioxidants and selected food groups and asthma in adults. Eur J Clin Nutr 2005;59:8-15.

  91. Visness CM, London SJ, Daniels JL, Kaufman JS, Yeatts KB, Siega-Riz AM, et al. Association of childhood obesity with atopic and nonatopic asthma: results from the National Health and Nutrition Examination Survey 1999-2006. J Asthma 2010;47:822-829.

  92. Shore SA. Obesity and asthma: cause for concern. Curr Opin Pharmacol 2006;6:230-236.

  93. Dixon AE, Shade DM, Cohen RI, Skloot GS, Holbrook JT, Smith LJ, et al. Effect of obesity and clinical presentation and response to treatment in asthma. J Asthma 2006;43:553-558.

  94. Crocker MK, Yanovsky JA. Pediatric obesity: etiology and treatment. Endocrinol Metab Clin North Am 2009;38:525-548.

  95. Delgado J, Barranco P, Quirce S. Obesity and asthma. J Investig Allergol Clin Immunol 2008;18:420-425.

  96. Wulster-Radcliffe MC, Ajuwon KM, Wang J, Christian JA, Spurlock ME. Adiponectin differentially regulates cytokines in porcine macrophages. Biochem Biophys Res Commun 2004:316:924-929.

  97. Torday JS, Sun H, Wang L. Leptin mediates the parathyroid hormonerelated protein paracrine stimulation of fetal lung maturation. Am J Physiol Lung Cell Mol Physiol 2002;282:L405-L410.

  98. Yamauchi T, Kamon J, Waki H, Yamauchi T, Kamon J, Waki H, et al. The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity. Nat Med 2001;7:941-946.

  99. Shore SA, Terry RD, Flynt L, Xu A, Hug C. Adiponectin attenuates allergen-induced airway inflammation and hyperresponsiveness in mice. J Allergy Clin Immunol 2006;118:389-395.

  100. Lilly CM, Woodruff PG, Camargo CA Jr, Nakamura H, Drazen JM, Nadel ES, et al. Elevated plasma eotaxin levels in patients with acute asthma. J Allergy Clin Immunol 1999;104:786-790.

  101. Al-Shawwa BA, Al-Huniti NH, Demattia L, Gershan W. Asthma an insulin resistance in morbidly obese children and adolescents. J Asthma 2007;44:469-473.

  102. Del-Rio-Navarro BE, Castro-Rodriguez JA, Garibay Nieto N, Berber A, Toussaint G, Sienra-Monge JJ, et al. Higher metabolic syndrome in obese asthmatic compared to obese nonasthmatic adolescent males. J Asthma 2010;47:501-506.




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