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ISSN 2007-4360 (Print)
Asociación Mexicana de Periodontología, Colegio de Periodoncistas A.C

2011, Number 3

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Rev Mex Periodontol 2011; 2 (3)

Proteomic analysis of cytokine expression in the gingival cervical fluid in HIV/AIDS carriers. Analytical essay

Elizondo OJE, Treviño FAC, Rocha PMR, Álvarez MM

Language: Spanish
References: 32
Page: 88-96
PDF size: 78.48 Kb.


ABSTRACT

Gingival crevicular fluid (GCF) proteomics technology can be used to assess periodontal disease progression and overall condition of patients with systemic diseases. Purpose: This paper examines whether the levels of IL-2, IL-4, IL-6, IL-8, IL-10, GM-CSF, IFN-γ, and TNF-α, are altered in patients with HIV/AIDS and whether CD4 T lymphocyte count, viral load and antiretroviral therapy (HAART), determine a difference. Materials and methods: 3 patients with HIV/AIDS, along with a healthy subject. The study was approved by the Ethics Committee and informed consents were obtained. Various parameters were analyzed in accordance with CDC, WHO (World Health Organization) and the EC-Clearinghouse on Oral Problems Related to HIV in the updated version of the Oral HIV/AIDS Research Alliance (OHARA). Results: Significant differences were observed in the expression of the cytokine profile of gingival crevicular fluid in HIV-1 carriers. Conclusion: Patients with HIV/AIDS have an increased inflammatory balance, high susceptibility to acquire periodontal disease, and the possible alteration in the oral microflora.


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