2012, Number 1
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Acta Pediatr Mex 2012; 33 (1)
Alterations in fetal nutrition and in early stages of life. Their impact on health in later stages of life
Perea-Martínez A, López-Navarrete GE, Carbajal-Rodríguez L, Rodríguez-Herrera R, Zarco-Román J, Loredo-Abdalá A
Language: Spanish
References: 22
Page: 26-31
PDF size: 314.42 Kb.
ABSTRACT
Obesity is a universal problema which affects all ages. It increases signigicantly in pregnant women. There is consistent epidemiological evidence that some adverse perinatal conditions are associated to a high risk for a future metabolic syndrome and related problems. Fetal programming and development are currently accepted concepts; however, the mechanisms involved are being investigated. Epigenetic disturbances, adipogenesis programming and appetite/saciety mechanisms are among the outstanding situations.
The importance of early weight gain, of feeding habits during the first months of life are assessed, all of which influence the preference of persons for certain foods. Based on these facts, special programs for prevention should be implanted in order to optimize neonatal health and to reduce the occurrence of disease in adults.
REFERENCES
Barker DJP, Osmond C, Goldings J, Kuh D, Wadsworth ME. Growth in utero, blood pressure in childhood and adult life, and mortality from cardiovascular disease. BMJ 1989; 298: 564-67.
Barker DJP, Winter PD, Osmond C, Margetts B, Simmonds SJ. Weight in infancy and death from ischaemic heart disease. Lancet 1989; 2: 577-80.
Curhan GC, Willet WC, Rimm EB, Spielgelman D, Ascherio AL, Stampfer MJ. Birth weight and adult hypertension, diabetes mellitus, and obesity in US men. Circulation 1996; 94: 3246-50.
Leon DA, Koupilova I, Lithell HO, Berglund L, Mohsen R, Vaguero D, Lithell VB, McKeigue PM. Failure to realice growth potential in utero and adult obesity in relation to blood pressure in 50 year old Swedish men. BMJ 1996; 312:401-6.
Luo ZC, Xiao L, Nuyt AM. Mechanisms of developmental programming of the metabolic syndrome and related disorders. World J Diabetes. 2010;1(3):89-98.
Becerra FA. Malnutrición fetal y enfermedad metabólica en la vida adulta. Nutrición y Obesidad 1999; 5: 243-51.
Salbaum JM, Kappen C. Diabetic embryopathy: A role for the epigenome? Birth Defects Res A Clin Mol Teratol 2011;91:770-80.
Desai M, Li T, Ross MG. Hypothalamic neurosphere progenitor cells in low birth-weight rat newborns: neurotrophic effects of leptin and insulin. Brain Res 2011;1378:39-42.
Desai M, Guan Han, Ferelli M, Lallichanda N, Lane RH. Programmed upregulation of adipogenic transcription factors in intrauterine growth-restricted offspring. Reprod Sci 2008;15:785-96.
Addel-Hakeem AK, Henry TQ, Magee TR, Desai M, Ross MG, Mansano RZ et al. Mechanism of impaired nephrogenesis with fetal growth restriction: altered renal transcription and growth factor expression. Am J Obstet Gynecol 2008;199:252-7.
Karadag A, Sakurai R, Wang Y, Guo P, Desai M, Ross MG, et al. Effect of maternal food restriction on fetal rat lung lipid differentiation program. Pediatr Pulmonol 2009;44:635-44.
Belkacemi L, Chen CH, Ross MG, Desai M. Increased placental apoptosis in maternal food restricted gestations: role of the fast pathway. Placenta 2009;30:739-51.
Khorram O, Khorram N, Momeni M, Han G, Halem J, Desai M et al. Maternal undernutrition inhibits angiogenesis in the offspring: a potential mechanism of programmed hypertension. Am J Physiol Regul Integr Comp Physiol 2007;293:R745-53.
Gluckman PD, Hanson MA, Morton SM, Pinal CS. Life-long echoes-a critical analysis of the developmental origins of adult disease model. Biol Neonate 2005;87:127-39.
Ong KK, Emmet PM, Noble S, Ness A, Dunger DB, team AS. Dietary energy intake at the age of 4 months predicts postnatal weight gain and childhood body mass index. Pediatrics 2006;117(3):e503-8.
Ong KK, Petry CJ, Emmett PM, Sandhu MS, Kiess W, Hales CN, Ness AR, Danger DB, ALSPAC Study Team. Insulin sensitivity and secretion in normal children related to size at birth, postnatal growth, and plasma insulin-like growth factor-I levels. Diabetología 2004;47:1064-70.
Towle HC. Glucose as a regulator of eukaryotic gene transcription. Trends Endocrinol Metab 2005;16:489-94.
Moreno VJM, Serra JD. Alteraciones en la nutrición fetal y efectos a largo plazo: ¿algo más que una hipótesis? Act Ped Esp 2001;59:573-81.
Mennella JA, Pepino MY, Reed DR. Genetic and environmental determinants of bitter perception and sweet preferences. Pediatrics 2005;115:216-22.
Beauchamp GK, Mennella JA. Flavor Learning and its Impact on Later Feeding Behavior. J Pediatr Gastroenterol Nutr 2009;48:S25-S30.
Perea MA, Carbajal RL, Rodríguez HR, Zarco RJ, Barrios FR, Loredo AA. Association of comorbidity with obesity in mexican children adn adolescents. Pediatrics 2008;121:S149-50.
Boney CM, Verma A, Tucker R, Vohr B. Metabolic Syndrome in Childhood: Association With Birth Weight, Maternal Obesity, and Gestational Diabetes Mellitus. Pediatrics 2005;115:290-6.