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Instituto Nacional de Neurología y Neurocirugía

2011, Number 3

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Arch Neurocien 2011; 16 (3)

Effect og glycine administration on motor function in rats after traumatic injury of the spinal cord

Paredes-Espinosa MA, Flores-Mondragón G, Perea-Paz JM, Martínez-Canseco CJ, Méndez-Heredia J

Language: Spanish
References: 46
Page: 119-124
PDF size: 184.04 Kb.


ABSTRACT

After traumatic spinal cord injury (TSCI) decrease glycine level. The effects of administration of glycine are not fully understood. Objetive: evaluate functional motor recovery of TSCI in rats after administration of glycine. Material and method: TSCI was made in T8, under anesthesia in two groups Wistar rats. One group received glycine (TSCI+GLI), the other (TSCI+VEH) and healty rats group received vehicle. After the lesion, the spasticity and motor performance was assessed after TSCI using beam-walking paradigm and the footprint analysis for 8 weeks. Results: after the lesion, spasticity and beam-walking and footprint analysis showed an important motor deficit. Moreover, a slightly improvement were observed in the TSCI+GLI group, although no significant differences were found when the TSCI+GLI and TSCI+VEH groups were compared. Conclusions: the motor alteration taken place by the TSCI was valued appropriately by the battery of tests used motor performance. The glycine didn’t produce an effect statistically significant on the recovery of the complex patterns of sensory-motor integration after the TSCI, suggesting the use of different glycine dose and of pharmaceutical that inhibit the formation of free radicals, inflammatory reaction, such cyclosporin-A, and deferoxamine to completely abolish the oxidative effect of ferrous iron.


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