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Instituto Nacional de Neurología y Neurocirugía

2011, Número 3

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Arch Neurocien 2011; 16 (3)


Efecto de la administración de glicina en la función motora de la rata después de lesión traumática de la médula espinal

Paredes-Espinosa MA, Flores-Mondragón G, Perea-Paz JM, Martínez-Canseco CJ, Méndez-Heredia J

Idioma: Español
Referencias bibliográficas: 46
Paginas: 119-124
Archivo PDF: 184.04 Kb.


RESUMEN

En la lesión traumática de la médula espinal (LTME) se disminuyen los niveles de glicina y los efectos de su administración no son completamente conocidos. Objetivos: examinar el efecto de la administración de glicina inmediatamente después de la lesión traumática aguda de la médula espinal sobre la función motora de la rata. Material y métodos: se realizó lesión traumática en la médula espinal (LTME) en T8, a dos grupos de ratas Wistar. Uno recibió inmediatamente después glicina (LTME+GLI), y el otro (LTME+VEH) y a un tercero sano vehículo. Evaluamos la función motora en la barra de equilibrio y el análisis de huellas después de la LTME, durante 8 semanas. Resultados: LTME produjo espasticidad. El análisis de huellas y la barra de equilibrio mostraron alteración motora importante. La recuperación funcional en el grupo LTME+GLI fue mejor, pero no tuvo significancia estadística con respecto al grupo LTME+VEH. Conclusiones: la alteración motora producida por la LTME fue valorada de manera adecuada por la batería de pruebas motoras empleadas. La glicina no produjo un efecto estadísticamente significativo sobre la recuperación de los patrones complejos de integración sensorimotora después de la LTME, sugiriendo la utilización de diferentes dosis de glicina y fármacos que afectan la formación de radicales libres, como la ciclosporina-A, la cual también es un agente anti-inflamatorio y desferrroxamina.


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