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2011, Number 2

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Rev Mex Ing Biomed 2011; 32 (2)

Trabecular bone: texture analysis in CT to improve osteoporosis diagnosis in Duchenne muscle distrophy patients

Castellanos ANP, Martínez CE, Gutierrez MJ

Language: English
References: 22
Page: 125-132
PDF size: 122.18 Kb.


ABSTRACT

In recent years, interest in bone mineral densitometry (BMD) for children has increased, mainly due to the varieties of disease that influence bone growth. Trabecular bone densitometry in CT from lumbar vertebra is usually used clinically as a good indicator of bone deterioration and fracture risk. Nevertheless, diagnosing osteoporosis in obese and Duchenne Muscle Distrophy (DMD) children by BMD has been difficult due to the attenuation of radiation dose by abdominal fat, which could lead to overestimation of the degree of bone deterioration. The present work is an effort to improve pediatric osteoporosis diagnostic efficacy by analyzing the trabecular bone texture via CT with two frequency based methods: fractal dimension with power spectrum (Dps) and wavelet packets (WP). Healthy young adults group in the peak bone mass was statistically compared (t-student) with osteoporotic women with either fractal dimension or the four WP energy bands, and the results suggested significant differences. Applying ANOVA to three DMD children groups classified by their z-score as having normal, low and very low bone mineral density, significant differences were also found. At last, when comparing the DMD pediatric groups with that osteoporotic women, great statistical significance was found for all texture indicators. Results shown that the introduced techniques for image texture analysis could quantify the trabecular bone deterioration; this may help to improve the osteoporosis diagnosis in overweight patients, in specific DMD children, where it is often a diagnostic challenge.


REFERENCES

  1. Brunetto OH. Osteoporosis en pediatría. Revista Argentina de Endocrinología y Metabolismo 2006; 43(2): 90-108.

  2. Gilsanz V, Pérez FJ, Campbell PP, Dorey FJ, Lee DC, Wren TAL. Quantitative CT reference values for vertebral trabecular bone density in children and Young adults. Radiology 2009; 250(1): 222-227.

  3. van Rijn RR, van der Sluis IM, Link TM, Grampp, S, Guglielmi G, Imhof H, Glüer C, Adams JE, van Kuijk C. Bone densitometry in children: a critical appraisal. Eur Radiology 2003; 13: 700-707.

  4. Bachrach LK. Editorial: Osteoporosis in children: Still a diagnostic challenge. J Clin Endocrinol Metab 2007; 92(6): 2030-2031.

  5. Kalkwarf HJ, Zemel BS, Gilsanz V, Lappe JM, Horlick M, Oberfield S, Mahboudi S, Fan B, Frederik M, Winer K, Shepherd JA. The bone mineral density in childhood study: bone mineral content and density according to age, sex and race. J Clin Endocrinol Metab 2007; 92(6): 2087-2099.

  6. Friecke O, Sumnik Z, Tutlewski B, Stabrey A, Remer T, Schoenau E. Local body composition is associated with gender differences of bone development at the forearm in puberty. Horm Res 2008; 70: 105-111.

  7. Nohara T, Ueda M, Ohta A, Sugimoto T. Correlation of body growth and bone mineral density measured by ultrasound densitometry of the calcaneus in children and adolecents. J Exp Med 2009; 219: 63-69.

  8. Uppot RN. Impact of obesity in radiology. Radiol Clin N Am 2007; 45: 231-246.

  9. Schindera ST, Nelson RC, Toth TL, Nguyen GT, Toncheva GI, DeLong DM, Yoshizumi TT. Effect of patient size on radiation dose for abdominal MDCT with automatic tube current modulation: phantom study. Am J Roentgenol 2008; 190: 100-105.

  10. Yanch JC. Increased radiation dose to overweight and obese patients from radiographic examinations. Radiology 2009; 252: 128-139.

  11. Bothwell JE, Gordon KE, Dooley JM, MacSween J, Cummings EA, Salisbury S. Vertebral fractures in boys with Duchenne muscular distrophy. Clin Pediatr 2003; 42: 353-356.

  12. Schara U, Mortier J, Mortier W. Long-Term steroid therapy in Duchenne muscular distrophy- positive results versus side effects. J Clin Neuromusc Dis 2001; 2: 179-183.

  13. Bianchi ML, Mazzanti A, Galbiati E, Saraifoger S, Dubini A, Cornelio F, Morandi L. Bone mineral density and bone metabolism in Duchenne muscular dystrophy. Osteoporosis Int 2003; 14: 761-767.

  14. Szulc P, Seeman E. Thinking inside and outside the envelopes of bone. Osteoporosis Int 2009; 20: 1281-1288.

  15. Southard TE, Southard KA. Detection of simulated osteoporosis in maxillae using radiographic texture analysis. IEEE Trans Biomed Eng 1996; 43(2): 123-132.

  16. Jiang C, Pitt RE, Bertram JEA, Aneshansley, DJ. Fractal-based image texture analysis of trabecular bone architecture. Med Biol Eng Comput 1999; 37: 413-418.

  17. Samarabandu J, Archarya R, Hausmann E, Allen K. Analysis of bone X-rays using morphological fractals. IEEE Trans Med Imaging 1993; 12(3): 466-470.

  18. Unser M. Texture classification and segmentation using wavelet frames. IEEE Trans Image Process 1995; 4(11): 1549-1560.

  19. Wang ZZ, Yong JH. Texture analysis and classification with linear regression model based on wavelet transform. IEEE Trans Image Process 2008; 17(8): 1421-1430.

  20. Karahaliou AN, Boniatis IS, Skiadopoulos SG, Sakellaropoulos FN, Arikidis NS, Likaki EA, Panayiotakis GS, Costaridou LI. Breast cancer diagnosis: Analyzing texture of tissue surrounding microcalcifications. IEEE Trans Inf Technol Biomed 2008; 12(6): 731-738.

  21. Lewiecki EM, Gordon CM, Baim S, Binkley N, Bilezikian JP, Kendler DL, Hans DB, Silverman S, Bishop NJ, Leonard MB, Bianchi ML, Kalkwarf HJ, Langman CB, Plotkin H, Rauch F, Zemel BS. Special report on the 2007 adult and pediatric position development conferences of the international society for clinical densitometry. Osteoporosis Int 2008; 19: 1369-1378.

  22. Huda W, Ogden KM, Khorasani MR. Converting dose-length product to effective dose at CT. Radiology 248: September 2008 Radiology, 248, 995-1003.




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