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2011, Número 2

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Rev Mex Ing Biomed 2011; 32 (2)


Síntesis y análisis de la biocompatibilidad y osteoconductividad de un composito hidroxiapatita/colágeno, implantado en el sacro de un perro

Martínez RE, Quiroz GA, Velasco VR, Rosa OG, González PM

Idioma: Español
Referencias bibliográficas: 24
Paginas: 119-124
Archivo PDF: 142.47 Kb.


RESUMEN

Se sintetizó un nuevo biomaterial mediante el método de precipitación húmeda con el fin de obtener un injerto óseo capaz de utilizarse en aplicaciones médicas. Se preparó una solución de CaCl2 198 mM y una solución 119 mM de (NH4)2HPO4 con agua destilada; ambas soluciones se mezclaron simultáneamente mientras que una solución de NH4OH era agregada lentamente mediante goteo, finalmente se agregaron 3 ml de colágeno. El precipitado obtenido fue lavado varias veces con agua destilada, filtrado y secado en una incubadora a 40 C. Las muestras fueron caracterizadas mediante difracción de rayos x (DRX), microscopia electrónica de barrido (SEM), espectroscopia de infrarrojo por transformadas de Fourier (FTIR). Se prepararon tres cubos de composito de 10 x 10 x 10 mm3 cada uno, y fueron implantados en el sacro de un perro hembra para comprobar osteointegración y biocompatibilidad, se realizaron estudios histológicos y radiográficos que mostraron el desarrollo de un callo óseo y la formación de hueso nuevo.


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