2011, Number 1
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TIP Rev Esp Cienc Quim Biol 2011; 14 (1)
La Vía Rb/E2f Y La Familia de Proteínas Represoras Polycomb en el Desarrollo de Cáncer
Dávalos-Salas MI, Recillas-Targa F
Language: Spanish
References: 79
Page: 38-50
PDF size: 209.28 Kb.
ABSTRACT
The coordinated contribution of the E2F-family of transcription factors is critical for the proper control of the cell
cycle with consequences in the cellular homeostasis. Such kind of regulation requires a renewed vision of the
control of the cell cycle through the basis of epigenetic mechanisms. One of such regulatory components is the
Polycomb Group (PcG) of proteins which have been involved in cancer development through the anomalous
regulation, at an epigenetic level, of tumour suppressor genes such as
BRC1, p16, and
p53, among others. In
particular, the tumour suppressor gene
Retinoblastoma (Rb) plays a central role in the regulation of the cell cycle
and is regulated by PcG proteins. The relationship among E2F members, PcG and Rb has not been examined
in detail. Here, we describe the epigenetic interaction among these proteins, their association with epigenetic
processes and their contribution to cancer development.
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