2011, Number 4
Oral alitretinoin: specific therapy for severe chronic eczema of the hands refractory to corticosteroids
Language: Spanish
References: 14
Page: 197-201
PDF size: 1386.06 Kb.
ABSTRACT
Eczema of the hands (EOH) is the most prevalent hand dermatosis and represents an important healthcare, social and personal, and occupational concern for affected individuals. There exist numerous therapies for EOH although with a very limited efficacy. The first line drugs for EOH are moderate to high potency topical corticosteroids. A considerable percentage of these patients do not respond to topical corticosteroid therapy, or just partially. Oral Alitretinoin has been shown to be effective and safe for the treatment of chronic hand eczema refractory to potent topical corticosteroids, and it has been specifically approved for this use. In this article we describe the case of a female patient diagnosed with severe EOH grave, resistant to all previous therapies (topical and systemic) and who was successfully treated with oral Alitretinoin at 30 mg/day, with very good tolerance to the drug.REFERENCES
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Ruzicka T, Larsen FG, Galewicz D, Horváth A, Coenraads PJ, Thestrup-Pedersen K. Oral alitretinoin (9-cis-retinoic acid) therapy for chronic hand dermatitis in patients refractory to standard therapy: results of a randomized, double-blind, placebo-controlled, multicenter trial. Arch Dermatol 2004; 140: 1453-9.
Ruzicka T, Lynde CW, Jemec GB, Diepgen T, Berth-Jones J, Coenraads PJ, Kaszuba A et al. Efficacy and safety of oral alitretinoin (9-cis retinoic acid) in patients with severe chronic hand eczema refractory to topical corticosteroids: results of a randomized, double-blind, placebo-controlled, multicentre trial. Br J Dermatol 2008;158: 808-17.