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ISSN 0210-5187 (Electronic)

2011, Number 3

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Med Cutan Iber Lat Am 2011; 39 (3)

Graft versus host disease and its cutaneous manifestations

Cardoza TMA, Ocampo-Candiani J

Language: Spanish
References: 23
Page: 95-105
PDF size: 5223.24 Kb.


ABSTRACT

Allogeneic transplantation became feasible in the early 1960s, after the identification and typing of the major histocompatibility complex (HLA). Allogeneic grafts initiate immune reactions related to histocompatibility. The severity of the reaction depends on the degree of incompatibility. Graft-versus-host disease (GVHD), the primary complication of clinical allogeneic bone marrow transplantation (BMT), is a systemic disease with prominent cutaneous manifestations. Characteristic skin involvement contributes to the morbidity associated with marrow transplants. GVHD is an immunological process in which activated donor lymphocytes mount an attack against recipient tissues. This process involves secretion of cytokines and recruitment of additional inflammatory cells. Therefore the severity of acute GVHD is one of the most important prognostic factors that predicts outcome of BMT. Familiarity with these reactions and their treatment is important for dermatologists involved in the care of marrow transplant recipients.


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