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Órgano Oficial de la Sociedad Mexicana de Ortopedia Pediátrica

2011, Number 1

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Rev Mex Ortop Ped 2011; 13 (1)

Osteosarcoma

Sánchez-Torres LJ, Santos-Hernández M

Language: Spanish
References: 50
Page: 10-19
PDF size: 147.27 Kb.


ABSTRACT

Osteosarcoma is the most common primary malignant bone tumor in children and adolescents. Clinically patients present with pain, swelling and palpable mass. The three most frequent locations are distal femur, proximal tibia and proximal humerus. Before perform a biopsy, we must complete the study of our patient with axial computed tomography of the lesion and chest (to search for lung metastases), magnetic resonance imaging of the primary site including the joint above and below (looking for skip metastases), and a total body radionuclide scan; then, to plane the biopsy. It must be taken in the hospital and by surgeon that will perform the definitive procedure. There are many types of osteosarcoma, but conventional osteosarcoma is diagnosed in 75 to 90% of cases. The treatment includes preoperative (neoadjuvant) chemotherapy and surgery with wide margins. Once you have reconfirmed the diagnosis, verified clear surgical margins, and determined the percentage of tumor necrosis, to continue with adjuvant chemotherapy. When is not possible to preserve the affected limb, radical surgery is indicated.


REFERENCES

  1. Picci P, Sangiorgi L, Caldora P, Benassi MS, Campanacci M: Histopatología del osteosarcoma. Rev Esp Cir Osteoart 1995; 30(178): 211–216.

  2. Brenner W, Bohuslavizki KH, Eary JF. PET Imaging of osteosarcoma. J Nucl Med 2003; 44(6): 930-942.

  3. Marina N, Gebhardt M, Teot L, Gorlick R. Biology and therapeutic advances for pediatric osteosarcoma. The Oncologist 2004; 9: 422-441.

  4. Murphey MD, Robbin MR, McRae GA, Flemming DJ, Temple HT, Kransdorf MJ. The many faces of osteosarcoma. RadioGraphics 1997; 17(5): 1205-1231.

  5. Hicks MJ, Roth JR, Kozinetz CA, Wang LL. Clinicopathologic features of osteosarcoma in patients with Rothmund-Thomson Syndrome. J Clin Oncol 2007; 25(4): 370-375.

  6. Cortés-Rodríguez R, Castañeda Pichardo G, Tercero-Quintanilla G. Guía de diagnóstico y tratamiento para pacientes pediátricos con osteosarcoma. Arch Inv Mat Inf 2010; II(2): 60-66.

  7. Abudu A, Sferopoulos NK, Tillman RM, Carter SR, Grimer RJ. The surgical treatment and outcome of pathological fractures in localized osteosarcoma. J Bone Joint Surg Br 1996; 78-B(5): 694-698.

  8. Mehlman ChT, Cripe TP. Osteosarcoma and its variants. Orthop Clin North Am 1996; 27(3): 575–581.

  9. Bispo JRZ, Camargo OP. Prognostic factors in the survival of patients diagnosed with primary non-metastatic osteosarcoma with poor response to neoadjuvant chemotherapy. Clinics 2009; 64(12): 1177-1186.

  10. Unni KK. Osteosarcoma. In: Unni KK. Dahlin’s bone tumors. General aspects and data on 11,087 cases. Lippincott-Raven Publishers. Fifth Edition 1996; 11: 143-183.

  11. Hansen MF. Genetic and molecular aspects of osteosarcoma. J Musculoskel Neuron Interact 2002; 2(6): 554-560.

  12. Messerschmitt PJ, Garcia RM, Abdul-Karim FW, Greenfield EM, Getty PJ. Osteosarcoma. J Am Acad Orthop Surg 2009; 17(8): 515-527.

  13. Bielack S, Carrle D, Casali PG. Osteosarcoma: ESMO Clinical recommendations for diagnosis, treatment and follow-up. Ann Oncol 2009; 20(Suppl 4): iv 137-iv 139.

  14. Scully SP, Ghert MA, Zurakowski D, Thompson Jr RC, Gebhardt MC. Pathologic fracture in osteosarcoma. J Bone Joint Surg Am 2002; 84-A(1): 49-57.

  15. Söderlund V, Skoog L, Unni KK, Bertoni F, Brosjö O, Kreicbergs A. Diagnosis of high-grade osteosarcoma by radiology and citology: a retrospective study of 52 cases. Sarcoma 2004; 8(1): 31-36.

  16. Wu H-TH, Chang Ch-Y, Lin J, Chen T-H, Chen W-M, Wang S-F. Preoperative MR imaging assessment of osteosarcoma: a radiological-surgical correlation. Chin J Radiol 2001; 26: 9-16.

  17. Erol B, Bezer M, Guven O. Evaluation of pediatric musculoskeletal tumors. Marmara Medical Journal 2004; 17(3): 140-145.

  18. Greenspan A, Jundt G, Remagen W. Bone-forming (osteogenic) lesions. In: Greenspan A, Jundt G, Remagen W. Differential diagnosis in orthopaedic oncology. Lippincott Williams & Wilkins. Second edition 2007; 2: 40-157.

  19. Enneking WF, Kagan A. “Skip” metastases in osteosarcoma. Cancer 1975; 36: 2192-2205.

  20. Enneking WF, Kagan A. The implications of “skip” metastases in osteosarcoma. Clin Orthop Relat Res 1975; 111: 33-41.

  21. Sim FH, Unni KK, Beaubout JW, Dahlin DC. Osteosarcoma with small cells simulating Ewing’s tumor. J Bone Joint Surg Am 1979; 61: 207-215.

  22. Murphey MD, Jaovisidha S, Temple HT, Gannon FH, Jelinek JS, Malawer MM. Telangiectatic osteosarcoma: radiologic-pathologic comparison. Radiology 2003; 229(2): 545-553.

  23. Phatak SV, Kolwadkar PK, Lawange A, Rajderkar D. Telangiectatic osteosarcoma: a case report. Ind J Radiolo Imag 2005; 15(3): 353-354.

  24. Klein MJ, Siegal GP. Osteosarcoma. Anatomic and histologic variants. Am J Clin Pathol 2006; 125: 555-581.

  25. Antonescu CR, Huvos AG. Low-grade osteogenic sarcoma arising in medullary and surface osseous locations. Am J Clin Pathol 2000; 114(Suppl 1): S90-S103.

  26. Jaffe HL. Intracortical osteogenic sarcoma. Bull Hosp Joint Dis 1960; 21: 189.

  27. De Boeck H, Handelberg F, Otten J. Unusual evolution of a benign-looping cortical defect of the proximal humerus. A case of intracortical osteosarcoma? Acta Orthop Belg 1998; 64(1): 96-99.

  28. Hermann G, Klein MJ, Springfield D, Abdelwahab IF, Dan SJ. Intracortical osteosarcoma; two-year delay in diagnosis. Skeletal Radiol 2002; 31(10): 592-596.

  29. Griffith JF, Kumta SM, Chow LTC, Leung PCh, Meetreweli C. Intracortical osteosarcoma. Skeletal Radiol 1998; 27(4): 228-232.

  30. López-Barea F, Rodríguez-Peralto JL, González-López J, Sánchez-Herrera S, Sánchez-Del Charco M. Intracortical osteosarcoma. A case report. Clin Orthop Relat Res 1991; 268: 218-222.

  31. Murphey MD, Jelinek JS, Temple HT, Flemming DJ, Gannon FH. Imaging of periosteal osteosarcoma: radiologic-pathologic comparison. Radiology 2004; 233(1): 129-138.

  32. Dönmez FY, Tüzün Ü, Basaren C, Tunaci M, Bilgiç B, Acunas G. MRI findings in parosteal osteosarcoma: correlation with histopathology. Diagn Interv Radiol 2008; 14(3): 147-152.

  33. Samardziski M, Zafiroski G, Tolevska C, Konstadinova-Kunovska S, Vasileva V. Diagnostic and treatment problems with parosteal osteosarcoma. A Clinical and histological study of 7 cases and review of the literature. Radiol Oncol 2007; 41(3): 152-160.

  34. Unni KK. Parosteal osteosarcoma. In: Unni KK. Dahlin’s bone tumors. General aspects and data on 11,087 cases. Lippincot-Raven Publishers. Fifth Edition 1996; 12: 185-196.

  35. Francis KC, Hutter RVP, Coley BL. Treatment of osteogenic sarcoma. In: Pack GT, Ariel IM, editors. Treatment of cancer and allied diseases. 2nd ed. New York: Harper & Row Publishers 1964; 8: 374-399.

  36. Okada K, Unni KK, Swee RG, Sim FH. High grade surface osteosarcoma. A clinicopathologic study of 46 cases. Cancer 1999; 85(5): 1044-1054.

  37. Vanel D, Picci P, De Paolis M, Mercuri M. Radiological study of 12 high – grade surface osteosarcoma. Skeletal Radiol 2001; 30: 667-671.

  38. Bertoni F, Bacchini P, Staals EL, Davidovitz P. Dedifferentiated parosteal osteosarcoma: The experience of the Rizzoli Institute. Cancer 2005; 103(11): 2373-2382.

  39. Wold LE, Unni KK, Beabout JW, Sim FH, Dahlin DC. Dedifferentiated parosteal osteosarcoma. J Bone Joint Surg Am 1984; 66-A(1): 53-59.

  40. Buzzoni R, Della Torre S, Cortinovis D, Catena L. Case report of synchronous multicentric osteosarcoma and review of the literature: the importance of autopsy for diagnosis. Tumori 2005; 91: 90-92.

  41. Silverman G. Multiple osteogenic sarcoma. Archives of Pathology 1936; 21: 88-95.

  42. Curral VA, Dixon JH. Synchronous multifocal osteosarcoma: case report and literature review. Sarcoma 2006: Article ID 53901.

  43. Sangüesa NMJ, Cabanes SF, Valverde MC. Osteosarcoma extraesquelético. Caso clínico. Revista Española de Cirugía Osteoarticular 2007; 43(230): 88-92.

  44. Nagano A, Ohno T, Nishimoto Y, Yamada K, Shimizu K. Extraskeletal osteosarcoma of the thigh: An autopsy case report. Sarcoma 2009: Article ID 186565.

  45. Wilson H. Extraskeletal ossifying tumors. Ann Surg 1941; 113(1): 95-112.

  46. Weiss ShW, Goldblum JR. Osseous soft tissue tumors. In: Weiss ShW, Doldblum JR. Enzinger & Weiss’s Soft tissue tumors. Mosby Elsevier. Fifth edition 2008; 34: 1039-1061.

  47. Hansen MF, Seton M, Merchant Anand: Osteosarcoma in Paget’s disease of bone. J Bone Miner Res 2007; 21: P58-P63.

  48. Álvarez HE, Hernández CCB. Osteosarcoma osteoblástico en un paciente con enfermedad de Paget del hueso. Comunicación de un caso y revisión bibliográfica. Med Int Mex 2006; 22(6): 559-564.

  49. McNairn JDK, Damron TA, Landas SK, Ambrose JL, Shrimpton AE. Inheritance of osteosarcoma and Paget’s disease of bone. A familial loss of heterozygosity study. J Molecular Diagnostics 2001; 3(4): 171-177.

  50. Longhi A, Errani C, Gonzáles-Arabio D, Ferrari C, Mercuri M. Osteosarcoma in patients older than 65 years. J Clin Oncol 2008; 26(33): 5368-5373.




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