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ISSN 0187-5337 (Print)
Instituto Nacional de Perinatología

2011, Number 1

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Perinatol Reprod Hum 2011; 25 (1)

Immune tolerance mechanisms during pregnancy

Vázquez-Rodríguez S, Bouchan-Valencia P, González-Jiménez MA, Paredes-Vivas LY, Calixto-González R, Cérbulo-Vázquez A

Language: Spanish
References: 25
Page: 39-45
PDF size: 198.09 Kb.


ABSTRACT

Immune tolerance in the maternal fetal interface is a natural event whereby the maternal immune system is not responding to the semiallogenic natural antigen represented by the fetus, cellular and molecular interactions by maternal and fetal immune systems provide the condition that allows pregnancy to develop in order to preserve the survival of the species. This review comments about the immunologic mechanisms that play an important role during pregnancy. The presence of uterine NK cells (NKu), the expression of HLA in placenta, the role of T lymphocytes and the function of the IDO enzyme (indoleamine 2, 3 dioxygenase). It is known that several mechanisms are involved in maternal-fetal tolerance, which begins from the moment of conception and continues until birth. Through the knowledge of immunology of pregnancy it is possible to understand the adaptation processes of the immune response, and create alternatives for manipulation of the immune response (as done in vaccination), that in the future may allow management of immunity to facilitate treatment in the field of organ transplantation and immunosuppressive drugs.


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