Avendaño RJM, Romero MB, Marín FME, Souza VM, Acosta VH, Jaramillo RH

Language: Spanish
References: 21
Page: 327-332
PDF size: 221.81 Kb.

ABSTRACT

Background: the correlation between the presence of anti-CagA antibodies and anti-VacA antibodies in patients with Helicobacter pylori and dyspepsia, neoplasia or peptic ulcer disease. We studied the prevalence of antibodies for anti-CagA and anti-VacA in patients with dyspepsia and the presence of peptic ulcer or neoplasia
Material and methods: Patients with dyspepsia from hospitalization and outpatient care of the Mexicali General Hospital where included for the realization of upper endoscopic study. Levels of anti-CagA and VacA where measured, and it was correlationated with the presence of neoplasia or peptic ulcer disease. We calculated mean and ED for the levels of IgG against CagA and VacA, parametric and no parametric tests were done to compare groups, according to the normal distribution of the population.
Results: A total of 41 patients with dyspepsia and clo-test positive where included. Three patients had a positive anti-VacA protein, and one positive for CagA. None of the patients with positive antibodies had endoscopic peptic ulcer disease or neoplasia.
Conclusion: The possibility of having a gastric, duodenal ulcer or neoplasia with positive antibodies against the VacA and CagA protein for Helicobacter pylori, in the population with dyspepsia in Mexicali General Hospital its practically null.

REFERENCES

1. Covacci A, Censini S, Bugnoli M, et al.. Molecular characterization of the 128-kDa immunodominant antigen of Helicobacter pylori associated with cytotoxity and duodenal ulcer. Proc Natl Acad Sci 1993; 90:5791-5795.

2. Ender Serin, Uður Yilmaz, Ganiye Künefeci, Birol Özer, et al. Serum positive cagA in patients with non-ulcer dyspepsia and peptic ulcer disease from two centers in different regions of Turkey. World J Gastroenterol 2003;9(4):833-835.

3. Go MF. What are the host factors that place an individual at risk for Helicobacter pylori-associated disease? Gastroenterology 1997; 113(Suppl 6): S15-S20.

4. Cover Tl, et al. Divergence of genetic sequences for the vacuolating citotoxin among Helicobacter pylori strains. J Biol Chem 1994; 269:10566-10573.

5. Dixon M and the participants in the international workshop on the histopathology of gastritis, Houston 1994. American Journal of Surgical Pathology 1996;20(10):1161-1181.

6. Warburton VJ, Everett S, Mapstone NP, Axon AT, et al. Clinical and histological associations of cagA and vacA genotypes in Helicobacter pylori gastritis. J Clin Pathol 1998; 51:55-56.

7. Jenks PJ, Megraud F, Labigne A. Clinical outcome after infection with Helicobacter pylori does not appear to be reliably predicted by the presence of any of the genes of the cag pathogenicity island. Gut 1998; 43:752-758

8. Yang JC, Wang TH, Wang HJ, Kuo CH, et al. Genetic analysis of the cytotoxin-associated gene and the vacuolating toxin gene in Helicobacter pylori strains isolated from Taiwanese patients. Am J Gastroenterol 1997;92:1316-1321

9. Ender Serin, Uður Yilmaz, et al. Serum positive CagA in patients with non-ulcer dyspepsia and peptic ulcer disease from two centers in different regions of Turkey. World J Gastroenterol 2003; 9(4):833-835.

10. Bloom BS. Alternative management strategies for patients with suspected peptic ulcer disease. Ann Intern Med 1995;123:260-268.

11. Bosques-Padilla FJ, et al. Comparison of Helicobacter pylori Prevalence in Symptomatic Patients in Northeastern Mexico with the Rest of the Country: Its Association with Gastrointestinal Disease. Archives of Medical Research 2003;34:60-63.

12. Graham D, Lew G, Klein P, Evans D, et al. Effect of treatment of Helicobacter pylori infection on the long term recurrence of gastric or duodenal ulcer. Ann Int. Med 1992;116:105-108.

13. Graham DY. Evolution of concepts regarding Helicobacter pylori: from a cause of gastritis to a public health problem [Editorial]. Am J Gastroenterol 1994;89:469-472.

14. Lamarque D, Gilbert T, Roudot-Thoraval F, Deforges L, et al. Seroprevalence of eight Helicobacter pylori antigens among 182 patients with peptic ulcer, MALT gastric lymphoma or nonulcer dyspepsia. Higher rate of seroreactivity against CagA and 35-kDa antigens in patients with peptic ulcer originating from Europe and Africa. European Journal of Gastroenterology & Hepatology 1999;11(7):721-726.

15. Manjunath SM, Desai ND, Alejander J, Patil S, et al. Can anti-Helicobacter pylori and anti-CagA antibodies be used to select patients with dyspepsia for gastroscopy? 2006 Jul-Sep; 27(3):122-6.

16. Marshall BJ, Warren JR Unidentified curved bacilli in the stomach of patients with gastritis and peptic ulceration. Lancet 1984; 1:1311-4.

17. NIH Consensus Conference Development Panel on Helicobacter pylori in peptic ulcer disease. JAMA 1994; 272: 65-69. Helicobacter pylori in peptic ulcer disease.

18. Theodore Rokkas, et al. Serologic detection of CagA positive Helicobacter pylori strains predicts the presence of peptic ulcer in young dyspeptic patients. Gastrointest Endosc 1999; 50:511-5.

19. Toro Rueda C, Garcia-Samaniego J, Casado Fariñas I, Rubio Alonso M, Baquero Mochales M. Clinical importance of the CagA and VacA proteins and of the host factores in the development of peptic ulcer in patients infected by Helicobacter pylori. 2003 Sep; 203(9):430-3

20. Tummuru MKR et al. Infect Immun 1993; 61:1799-809. Cloning and expression of a high-molecular-mass major antigen of Helicobacter pylori: evidence of linkage to cytotoxin production.

21. Yusuf Erzin, Sibel Altun et al. World J Gastroenterol 2006 November 14; 12(42): 6869-6873. Analysis of serum antibody profi le against H pylori VacA and CagA antigens in Turkish patients with duodenal ulcer