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Instituto de Seguridad y Servicios Sociales de los Trabajadores del Estado

2009, Number 2

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Rev Esp Med Quir 2009; 14 (2)

Effect of sodium fluoride ingest on malondialdehyde level and activity of antioxidant enzymes in the rat erythrocyte

Gutiérrez SJ, Cruz TL, Chima GMC, García OL, Pérez RJC

Language: Spanish
References: 29
Page: 71-77
PDF size: 299.95 Kb.


ABSTRACT

Objective: To determine the effects on malondialdehyde levels in erythrocyte membranes and the activity of antioxidant enzymes from rats treated with sodium fluoride.
Material and methods: Male Wistar rats were divided in the following study groups: 1) controls; 2) experimental animals treated with NaF to 50 ppm. They were sacrificed every week until for eight weeks. Erythrocytes were isolated and malondialdehyde, superoxide dismutase and catalase were determined.
Results: Intake of NaF produces an increase in malondialdehyde only at eight weeks of treatment. Antioxidant enzymes were altered at four weeks of treatment.
Conclusions: Intake of NaF produces alterations in the erythrocyte of male rats as an indicative of oxidative stress.


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