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Instituto de Seguridad y Servicios Sociales de los Trabajadores del Estado

2010, Number 3

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Rev Esp Med Quir 2010; 15 (3)

Four primary cancers in a female patient. A report of a case

Cortés CSA, Ortega MBA, Murillo CDA, Torres AH, Hernández HB, Pedraza AYA

Language: Spanish
References: 14
Page: 173-176
PDF size: 52.43 Kb.


ABSTRACT

Multiple primary tumor (MPT) was defined by the International Agency for Research on Cancer (IARC) as the existence of two or morecancers that are no extension, recurrence or metastases having different locations or being located in the same place with different histology. This paper reports the case of a 72-year-old female who at 41 years old was diagnosed with breast cancer, with no recurrence evidence. Twenty-three years later, a moderately differentiated solid papillary adenocarcinoma was diagnosed. She was treated with suboptimal citorreductive surgery and was classified as IIIC stage, receiving six chemotherapy cycles. Two years later she presented with an elevation of CA-125 and a new pelvic tumor was diagnosed, a secondary optimal citorreductive surgery was performed with the histology diagnose of papillary adenocarcinoma grade 2, she received eight chemotherapy cycles. After a disease-free period of 20 months, CT scan diagnosed a tumor in left hypochondrium, patient was treated with optimal cytorreductive surgery. The histology diagnose was mixed müllerian tumor with heterologous components and she received six chemotherapy cycles. Twenty-four months later she presented an elevation of CA-125 with no evidence by CT scan of the tumoral activity, a PET-CT was performed, finding concentration of the radiomarker at the left subdiaphragmatic area, spleen, stomach and peripancreatic nodes. Another optimal citorreduction was performed with splenectomy, total gastrectomy and reconstruction. The pathology report was a moderately differentiated gastric adenocarcinoma. The patient coursed with a complicated postoperatory period, dying eight days after the surgery.


REFERENCES

  1. Lana Pérez A, Folgueras Sánchez MV, Díaz Rodríguez S, Del Valle Gómez MO, et al. Análisis de la supervivencia en pacientes con cáncer múltiple. Asturias 1975-2004. Rev Esp Salud Pública 2008;82:167-177.

  2. Billroth T. Die Allgemeine Chirurgische Pathologie and Therapie. In: Reamer G. 51 Vorlesungen-Ein Handbuch fur Studierende and Artze, 14, Berlin: Auflage, 1889.

  3. Zaher K, Otroc, Rami A, Mahfouz R, Ziad MS. Four primary tumors of lung, bladder, prostate, and breast in a male patient. South Med J 2005;98(9):945-948.

  4. González-Bosquet E, Quesada E, Lailla JM. Múltiples neoplasias malignas primarias en una mujer fumadora. Ginecología y Obstetricia Clínica 2003;4(3):167-169.

  5. Kulkarni D, Miller GAB. Multiple primary neoplasms developing in a case of prostate cancer. Ulster Med J 2003;72(1):55-57.

  6. Clarke EA, Kreiger N, Spengler RF. Second primary cancer following treatment for cervical cancer. Can Med Assoc J 1984;131:553-556.

  7. Kapp DS, Fischer D, Grady KJ, Schwartz PE. Subsequent malignancies associated with carcinoma of the uterine cervix: including an analysis of the effect of patient and treatment parameters on incidence and sites of metachronous malignancies. Int J Radiat Oncol Biol Phys 1982;8:197-205.

  8. Hessman O, Skogseid B, Westin G, Akerström G. Multiple allelic deletions and intratumoral genetic heterogeneity in men1 pancreatic tumors. J Clin Endocrinol Metab 2001;86(3):1355-1361.

  9. Shih HA, Nathanson KL, Seal S, Collins N, et al. BRCA 1 and BRCA 2 mutations in breast cancer families with multiple primary cancers. Clin Cancer Res 2000;6(11):4259-4264.

  10. Sprogel P, Karkov JN. Multiple primary cancers. Presence of more than 4 primary cancers. Ugeskr Laeger 1990;153(1):27-29.

  11. De Vita VT, Lawrence TS, Rosenberg SA, editors. Cancer principles and practice of oncology. 8th ed. Philadelphia: Lippincott Williams & Wilkins, 2008.

  12. Cokelaere K, Michielsen P, De Vos R, Sciot R. Primary mesenteric malignant mixed mesodermal (müllerian) tumor with neuroendocrine differentiation. Mod Pathol 2001; 14(5):515-520.

  13. Garde JR, Jones MA, McAfee R, Tarraza HM. Extragenital malignant mixed müllerian tumor: review of the literature. Gynecol Oncol 1991;43(2):186-190.

  14. Stojiljkovic B, Ivkovic T, Panjkovic M, Mutibaric A, et al. Malignant mixed müllerian ovarian tumor. Arch Oncol 2001;9(1):43-45.




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