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Instituto de Seguridad y Servicios Sociales de los Trabajadores del Estado

2010, Number 4

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Rev Esp Med Quir 2010; 15 (4)

Triple-negative breast cancer, current state

Olaya GEJ

Language: Spanish
References: 81
Page: 228-236
PDF size: 91.56 Kb.


ABSTRACT

Due to breast cancer is the most frequent cancer in women, there have been done many efforts to classify it in base of its genetic profile and immunohistochemical staining profile. Triple-negative breast cancer is defined by a lack of expression of estrogen and progesterone receptor as well as human epidermal growth factor receptor 2. It represents 15% of all types of breast cancer and arise more frequently in premenopausal Afro-American women. They are characterized by different molecular, histological and clinical features, particularly including the poor prognostic in spite of their high sensitivity to standard chemotherapy. They have been associated to breast cancer “basal-like” for their similarities, although not synonymous, there are still doing efforts for differentiate them by routine pathology techniques. In addition to the revision of these features, we focus in the current treatment and the possible target therapies in agreement to the molecular dysfunctions characteristic of this subgroup, including the implications of the BRCA1 dysfunction.


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