Díaz CJ, Domínguez GG

Idioma: Español
Referencias bibliográficas: 38
Paginas: 221-227
Archivo PDF: 74.60 Kb.

RESUMEN

La quimiorresistencia y radiorresistencia de las células cancerosas son los principales obstáculos en el tratamiento y manejo del cáncer. Un importante mecanismo que permite el desarrollo de resistencia a la terapia es que las células cancerosas reconocen el daño al ADN inducido por agentes quimioterapéuticos y por la radiación ionizante y lo reparan mediante la activación de diversas vías de reparación de ADN. Por tanto, inhibidores de vías específicas de reparación del ADN podrían aumentar la eficacia de los agentes quimioterapéuticos que inducen lesiones en el ADN, así como revertir la resistencia terapéutica asociada con la reparación del ADN. En este artículo se revisan las principales vías de reparación y se discuten los avances recientes en el desarrollo de nuevos inhibidores de las vías de reparación del ADN, muchos de los cuales se encuentran actualmente en fases preclínicas y clínicas de investigación.

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