2004, Number 4
<< Back Next >>
Cir Cir 2004; 72 (4)
Cost analysis: metronidazole-amikacin vs. preoperative monodose of ceftriaxone in appendicitis. Preliminary report
Baeza-Herrera C, Jaimes G, Rico-Mejía E, Sanjuan-Fabián H
Language: Spanish
References: 21
Page: 277-280
PDF size: 70.98 Kb.
ABSTRACT
Introduction: Postoperative management of acute appendicitis in our country has been supported by results from studies overseas. Ampicillin, clindamycin and gentamicin is the classic association of antimicrobial drugs. However, it is expensive, unnecessary and risky. We believe that a single dose can be useful.
Material and methods: We studied two groups comprised of 82 patients each in whom an appendectomy was performed. In group A an intravenous (i.v.) dose of ceftriaxone was given 30-240 minutes before skin incision. Group B or control group was comprised by the same number of patients previously operated and managed under traditional method (amikacin-metronidazole).
Results: In group A, three wound infections and an intraperitoneal abscess were identified, while in group B only one wound infection was seen. Average cost for patients in group A was 2,108.91 pesos (approx. $200 USD). In group B, the average cost was 9,407.48 pesos (approx. $900 USD).
Conclusions: One dose of preoperative ceftriaxone proved to be most financially economical.
REFERENCES
Meller LJ, Reyes MH, Loeff SD, et al. One-drug versus two drugs antibiotic therapy in pediatric perforated appendicitis: a prospective randomized study. Surgery 1991;110:764-768.
Pearl HP, Hale DA, Molloy M, et al. Pediatric appendectomy. J Pediatr Surg 1995;30:173-181.
Baeza HC. Manual de Procedimientos. Departamento de Cirugía. Hospital Pediátrico Moctezuma. 2002.
Schwartz MZ, Tapper D, Solenberger RI. Management of perforated appendicitis in children. J Pediatr Surg 1983;197:407-411.
Hickey SM, McCraken GH. Antibacterial therapeutic agents. In: Feigin RD, Cherry JD, editors. Textbook of pediatric infectious disease. 4th ed. Philadelphia: WB Saunders; 2000. pp. 2620-2625.
Cloud DT. Apendicitis. En: Ashcraft KW, Holder TM, editores. Cirugía pediátrica. 2ª edición. México: Interamericana-McGraw-Hill; 1995. pp. 484-491.
Willis AT, Ferguson IR, Jones PH, et al. Metronidazol in prevention and treatment of bacteroides infections after appendectomy. Br Med J 1976;1:318-321.
David BI, Buck RJ, Filler MR. Rational use of antibiotics for perforated appendicitis in childhood. J Pediatr Surg 1982;17:494-500.
Gibert RS, Emmens WR, Putnam CT. Appendicitis in children. Surg Gynecol Obstet 1985;161:261-266.
Campbell WB. Prophylaxis of infection after appendectomy: a survey of current surgical practice. Br Med J 1980;281:1598-1601.
Ford WDA, MacKellar A, Richardson CJL. Pre- and postoperative rectal metronidazole for the prevention of wound infection in childhood appendicitis. J Pediatr Surg 1980;15:160-163.
Shandling B, Ein HS, Simpson SJ, et al. Perforating appendicitis and antibiotics. J Pediatr Surg 1974;9:79-83.
Leigh AD, Pease R, Henderson H, et al. Prophylactic lincomycin in the prevention of wound infection following appendectomy: a double blind study. Br J Surg 1976;63:973-977.
Mosdell MD, Morris MD, Fry ED. Peritoneal cultures and antibiotic therapy in pediatric perforated appendicitis. Am J Surg 1994;167: 313-316.
Pokorny JW, Kaplan LS, Mason OE. A preliminary report of ticarcillin and clavulanate versus triple antibiotic therapy in children with ruptured appendicitis. Surg Gynecol Obstet 172(Suppl):54-56.
Winslow RE, Dean RE, Harley JW. Acute nonperforating appendicitis. Arch Surg 1983;118:651-655.
Busuttil RW, Davidson RK, Fine M, et al. Effect of prophylactic antibiotics in acute nonperforated appendicitis. Ann Surg 1981;194: 504-509.
Pinto DJ, Sanderson PJ. Rational use of antibiotic therapy after appendectomy. Br Med J 1980;2:175-178.
Gutiérrez C, Vila J, García-Sala C, et al. Study appendicitis in children treated with four different antibiotic regimens. J Pediatr Surg 1987;22:865-868.
Bauer T, Vennits B, Holm B, et al. Antibiotic prophylaxis in acute nonperforated appendicitis. The Danish Multicentric Study Group 111. Ann Surg 1989;209:307-311.
Schropp PK, Kaplan S, Golladay ES, et al. A randomized clinical trial of ampicillin and clindamycin versus cefotaxime and clindamycin in children with ruptured appendicitis. Surg Gynecol Obstet 1991;172:351-356.