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Patología Revista Latinoamericana

2010, Number 2

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Patol Rev Latinoam 2010; 48 (2)

Vascular abnormalities in inflammatory bowel disease in a group of children

Acevedo GE, Serrano BC, Worona DL, Consuelo SA, Valencia MP

Language: English
References: 53
Page: 93-99
PDF size: 343.05 Kb.


ABSTRACT

Objectives: To determine the presence of vascular changes in colonic biopsies of children with intestinal bowel disease (IBD) and to describe them.
Material and methods: This is a case-control retrospective study of 16 patients with IBD and 32 control patients with intestinal bleeding carried on at Hospital Infantil de México Federico Gómez. Clinical data and laboratory results were obtained from clinical charts; colonic biopsies from the Department of Pathology were reviewed. Vasculitis, endothelialitis and pavementing leukocytes vessel were searched.
Results: Leukocyte pavementing vessel and endothelialitis predominated in cases (p = 0.03 and p = 0.001), as well as endothelialitis with polymorphonuclear leukocyte (p ‹ 0.001) and with mononuclear cells (p = 0.03), the overall vascular damage was extense in twelve cases and five controls (p ‹ 0.001), the overall intensity of vascular damage was severe in eight cases and two controls (p ‹ 0.001). In the follow-up colonic biopsies, vascular damage and laboratory data of activity were found.
Conclusions: Vascular changes were significantly present in patients with IBD; they may be part of the pathogenesis of damage to the mucose and at the same time maybe indicators of disease activity.


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