Leonardo JD, Ramos SP, Millán RV, Valenzuela TJ, Zárate OA

Language: Spanish
References: 34
Page: 73-81
PDF size: 415.22 Kb.

ABSTRACT

Background: Solitary fibrous tumor (SFT) is a rare neoplasm originally described within the pleura. Extrapleural solitary fibrous tumors (EPSFT) have been recently reported and described in practically any anatomic location, which has widenned the differential diagnosis, in relation to some soft tissue tumors, particularly the hemangiopericytoma.
Objective: To determine from the histopathological and immunohistochemistry point of view the differencial diagnosis of 18 cases with extrapleural solitary fibrous tumor.
Material and method: We retrieved 18 cases diagnosed as EPSFT from January 2001 through October 2008. There were nine women; the age range was from 26 to 74, with a mean age at diagnosis of 48.72 years. The most common site was the nasal cavity and paranasal sinuses (4 cases).
Results: The immunostains showed the neoplastic cells positive for CD34 (100%), bcl-2, and CD99 (88.9%), whereas only 22% showed focal and weak positivity for actin, and 11% for desmin.
Conclusion: EPSFT is a rare tumor with a morphology that resembles hemangiopericytoma and other soft tissue tumors and, in order to establish a correct diagnosis, it requires immunoperoxidase stains. It shows immunoreactivity with CD34, bcl-2 and CD99, and is consistently negative for cytokeratin, S-100 and CD117. Muscles markers, such as actin and desmin, might be focally expressed.

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