Arellano-Reynoso A

Language: Spanish
References: 39
Page: 233-241
PDF size: 566.55 Kb.

ABSTRACT

From the cellular, biochemical and functional point of view the pedunculopontine nucleus (PPN) is an heterogeneous structure. The PPN is part of the «mesencephalic motor region» and it has been found to participate in initiating and maintaining movement. From the therapeutic point of view, it has been found that Parkinson’s disease animal models show improvement with activation and worsening with inhibition of this nucleus. Only recently have some neurosurgical teams made the first surgical interventions on this structure on human beings, and with these interventions gathered information about registering and clinical response to electrical stimulation during surgery. To locate this structure, we have the aid of images, stereotaxic atlases, micro registering and clinical response of the patient during surgery. All of these tools must be used in a cooperative fashion in order to obtain the best clinical response and to reduce risk as much as possible. Today, the intervention on this nucleus is seen as a possible therapy for L-Dopa resistant axial symptoms in patients with Parkinson’s disease and other parkinsonic syndromes.

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