Arellano-Reynoso A

Idioma: Español
Referencias bibliográficas: 39
Paginas: 233-241
Archivo PDF: 566.55 Kb.

RESUMEN

El núcleo pedúnculo pontino (NPP) es una estructura heterogénea desde el punto de vista celular, bioquímico y funcional. Forma parte de la región mesencefálica motora de forma extensa y se ha demostrado a través de estudios en modelos animales su participación en iniciación y mantenimiento del movimiento. Desde el punto de vista terapéutico se ha encontrado que los modelos animales de enfermedad de Parkinson presentan mejoría con activación y empeoran con la inhibición de este núcleo. Recién se ha realizado las primeras intervenciones quirúrgicas sobre esta estructura en seres humanos, con ellas se ha obtenido información acerca del registro eléctrico y respuesta de los pacientes con la estimulación eléctrica. Para la localización de esta estructura se cuenta en la actualidad con apoyo de estudios de imagen, atlas de estereotaxia, uso de microrregistro transoperatorio, estimulación y valoración del paciente durante dicho procedimiento. Todos estosrecursos de localización deben ser utilizarse de manera conjunta para mejorar resultados y disminuir al mínimo los riesgos de este procedimiento. Ahora, la intervención sobre este núcleo se vislumbra como una posibilidad de tratamiento de síntomas axiales resistentes a L-dopa en pacientes con enfermedad de Parkinson y otros síndromes parkinsónicos.

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