medigraphic.com
Organo Oficial de la Sociedad Mexicana de Urología

2011, Number 1

<< Back Next >>

Rev Mex Urol 2011; 71 (1)

Cáncer de pene; presentación de 10 casos

Arroyo C, Hernández-Molina J, Soto-Vega E

Language: Spanish
References: 29
Page: 40-46
PDF size: 134.14 Kb.


ABSTRACT

Objective: To report ten cases of carcinoma of the penis and evaluate their management at a university hospital.
Methods: A descriptive, retrospective study of patients that presented with penile cancer within the last five years at the Hospital Universitario de Puebla is presented. Only cases with histopathological diagnosis and complete case record were included.
Results: Ten patients with penile cancer with mean age of sixty-three years at time of diagnosis are presented. All were cases of epidermoid cancer. Disease was localized in the glans and prepuce in eight patients, in the base of the penis in one patient, and in the body of the penis in one patient. The most frequent presentation was a bleeding ulcer in seven patients and a verrucous lesion in three patients. Clinical stage was T1N0M0 in five patients, T2N0M0 in two patients, and advanced stage in three patients. Seven patients were managed with partial penectomy (three with inguinal lymphadenectomy), two with radical penectomy, and one with radiochemotherapy. Follow-up varied from two to fifty- three months with one death at six months from diseaseprogression, one death at three months from sepsis, and one death at three years from lymph node metastasis. The remaining patients have had no evidence of tumor disease.
Conclusions: The present study results confirm the fact that early stage disease with adequate surgical treatment has good prognosis, concurring with similar encouraging results in the literature.


REFERENCES

  1. Barnholtz-Sloan JS, Maldonado JL, Pow-sang J, Giuliano AR. Incidence trends in primary malignant penile cancer. Urol Oncol 2007;25:361-7.

  2. Prowse DM, Ktori EN, Chandrasekaran D, et al. Human papillomavirus associated increase in p16 (INK4A) expression in penile lichen sclerosus and squamous cell carcinoma. Br J Dermatol 2008;158:261-5.

  3. Gross, Pfister. Role of human papillomavirus in penile cancer, penile intraepithelial squamous cell neoplasias and in genital warts. Med Microbiol Immunol 2004;193:35-44.

  4. Mare, Goodman, Hernández, Shvetsov. Demographic and pathologic differences in the incidence of invasive penile cancer in the United States, American Association for Cancer Research. Cancer Epidemiol Biomarkers Prev 2003;16:1833-1839.

  5. Allepuz Losa C, Borque Fernando Á, Rioja Sanz LA. ¿Cuál es el algoritmo diagnóstico más apropiado para el cribado del cáncer de próstata? Actas Urol Esp 2005;29:465-72.

  6. Solsona Carbón E. Cáncer de pene. Actas Urol Esp 2002;26:525-31.

  7. Soto Delgado, Arredondo Martínez F, Pedrero Márquez G, et al. Cáncer de pene. Una revisión de 18 casos. Actas Urol Esp 2003;27:797- 802.

  8. Hadway P, Smith Y, Corbishley C, et al. Evaluation of dynamic lymphoscintigraphy and sentinel lymph-node biopsy for detecting occult metastases. BJU Int 2007;100,561-65.

  9. Spiess PE, Izawa JL, Bassett R. Preoperative lymphoscintigraphy and dynamic sentinel node biopsy for staging penile cancer: Results with pathological correlation. J Urol 2007;177:2157-61.

  10. Loughlin K. Is sentinel node biopsy indicated in penile cancer. Nat Clin Pract Urol 2007;4:80-1.

  11. Poetsch M, Schuart BJ, Schwesinger G, et al. Screening of microsatellite markers in penile cancer reveals differences between metastatic and nonmetastatic carcinomas. Mod Pathol 2007;20:1069-77.

  12. Jariwala SK, Lambe S, Mammen KJ. Surgical Management of Penile Carcinoma: The Primary Lesion. BJU Int 2006;98:917-8.

  13. McDougal WS. Phallic preserving surgery in patients with invasive squamous cell carcinoma of the penis. J Urol 2005;174:2218-20.

  14. Nelson BA, Cookson MS, Smith JA Jr, et al. Complications of inguinal and pelvic lymphadenectomy for squamous cell carcinoma of the penis a contemporary series. J Urol 2004;172:494-7.

  15. Mohs FE, Lathrop TG. Modes of spread of cancer of the skin. AMA Arch Derm Syphilol 1952;66:427-39.

  16. Cuevas de Eusebio, Díez Castiñeira. Cirugía de Mohs: Aplicación de la técnica a neoplasias del pene. Actas Urol Esp 2007;31:1076-81.

  17. Algaba F, Arce Y, Santaularia JM. La biopsia intraoperatoria en patología

  18. Bermejo C, Busby JE, Spiess PE, et al. Neoadjuvant chemotherapy followed by aggressive surgical consolidation for metastatic penile squamous cell carcinoma. J Urol 2007;177:1335-8.

  19. Ozsahin M, Jichlinski P, Weber DC, et al. Treatment of penile carcinoma: To cut or not to cut? Int J Radiat Oncol Biol Phys 2006;66:674- 9.

  20. Lont AP, Gallee MP, Meinhardt W, et al. Penis conserving treatment for T1 and T2 penile carcinoma: clinical implications of a local recurrence. J Urol 2006;176:575-80.

  21. Poetsch M, Schuart BJ, Schwesinger G, et al. Screening of microsatellite markers in penile cancer reveals differences between metastatic and nonmetastatic carcinomas. Mod Pathol 2007;20:1069-77.

  22. Hegarty PK, Kayes O, Freeman A, et al. A prospective study of 100 cases of penile cancer managed according to European Association of Urology guidelines. BJU Int 2006;98:526-31.

  23. Mistry. T, Jones. R, Dannatt. E, Prasad. K, Andrew. D. Stockdale AD. A 10 year retrospective audit of penile cancer management in the UK. BJU Int 2007;100:1277-81oncológica urológica. Actas Urol Esp 2007;31:945-56.




2020     |     www.medigraphic.com