Julio CN, Casco FG , Pianzola HM, Ottino A

Language: Spanish
References: 17
Page: s14-s17
PDF size: 371.00 Kb.

ABSTRACT

Langerhans’ cell histiocytosis (LCH) is an unusual neoplasm of unknown etiology, associated with neoplasms and autoimmune diseases. It has diverse manifestations and localizations, and may be uni or multifocal. In 1953, Lichtenstein established the term histiocytosis X, to include three related diseases with the presence of Langerhans’ cells: eosinophilic granuloma, Hand-Schüller-Christian and Letterer- Siwe diseases. In 1973, Nezelof suggested the term Langerhans’ cell histiocytosis. This paper reports the case of a 24-year-old female, with a nodule in the right thyroid lobe attended to consultation. Fine needle aspiration, surgery and frozen section were performed. The diagnosis was papillary carcinoma (PTC). Right parathyroid gland (RP), left thyroid lobe (LTL) and anterior cervical lymph nodes (ACLN) were removed. The delayed analysis did not showed abnormalities in LTL and RP. The ACLN specimen showed thymus remnants without carcinomatous involvement, and a diffuse proliferation of cells with wide cytoplasm and grooved nuclei, surrounded by eosinophils. Immunohistochemistry (IHC) for CKAE1-AE3 (Zimed), S100 (Zimed) and CD1a (Dako), showed positivity for both S100 and CD1a. The morphology and IHC corresponded to LCH. Thymic involvement as an exclusive localization is unusual, and the association with PTC has only been reported in cervical lymph nodes. So far we are not aware of any reported similar cases in the literature.

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