medigraphic.com
ISSN 0185-3252 (Print)
Revista de la Asociación Médica del Centro Médico ABC

2011, Number 1

<< Back Next >>

An Med Asoc Med Hosp ABC 2011; 56 (1)

Thrombosis associated to sticky platelet syndrome

Núñez-Martínez ME, Martínez-Murillo C, Simón-Domínguez JI, Pizzuto-Chávez J

Language: Spanish
References: 27
Page: 5-10
PDF size: 120.28 Kb.


ABSTRACT

Introduction: The Sticky Plateler Syndrome (SPS), associated with arterial and venous thromboembolic events in young subjects. Objective: To determine the incidence and promote the analysis of patients with CM ABC of SPS over six years of study. Material and methods: It is a cross sectional study from 2003 to 2008, which included patients with a history of arterial or venous thrombosis and who are conducting studies to determine hyperaggregability platelet with ADP and epinephrine.We analyzed variables such as gender, age, background heredofamiliar, medical history, diagnosis, treatment and complications. To use the statistical analysis. Results: Were obtained from 967 patients with a history of thrombosis 525 with arterial thrombosis and 442 with venous thrombosis, of whom 25 had hyperaggregability and were classified according to criteria established by Mammen, Of all the additions, 17 (68%) corresponded to type I, three (12%) type II and five (20%) type III. Fourteen patients are female (56%) and 11 males (44%) in 1.2:1 ratio. The median age was 56 years for both genders with a range of 28 to 78 years. The prevalence of SPS corresponds to 2.58 in six years. Conclusion: The study is the beginning of a line of research that aims to raise awareness of the importance of the SPS basically related to idiopathic thrombotic events.


REFERENCES

  1. Holliday PL, Mammen EF, Gilroy J et al. Sticky platelet syndrome and cerebral infarction in young adults. Nineth Int Joint Conf on Stroke and Cerebral Circulation. Phoenix, AZ, 1983.

  2. Velazquez A et al. El síndrome de plaquetas pegajosas. Rev Obst Ginecol 2004; 55 (3): 232-239.

  3. al-Mefty O, Marano G, Rajaraman S, Nugent GR, Rodean N. Transient ischemic attacks due to increased platelet aggregation and adhesivenness. Ultrastructural and functional correlation. J Neurosurg 1979; 50: 449-453.

  4. Mammen EF, Comp PC, Gosselin R, Greenberg C, Hoots WK, Kessler C et al. PFA-100 System: A new method for assessment of platelet dysfunction. Semin Thromb Hemostat 1998; 24: 195-202.

  5. Rubenfire M, Blevins RD, Barnhart M, Housholder S, Selik N, Mammen EF. Platelet hyperaggregability in patients with chest pein and angiographically normal coronary arteries. Am J Cardiol 1986; 57: 657-660.

  6. Mammen EF. Ten years experience with the sticky platelet syndrome. Clin Appl Thromb Hemost 1995; 1: 66-72.

  7. Born GVR. Quantitative investigations into the aggregations of blood platelet. J Physiol 1962; 162: 67-71.

  8. Mammen EF. Sticky platelet syndrome. Sem ThrombHemost 1999; 25: 361-365.

  9. Patrono C. Aspirin as an antiplatelet drug. N Engl J Med 1994; 330: 1287-1294.

  10. Ruiz-Argüelles GJ, López-Martínez B, Cruz-Cruz D, Reyes-Aulis MB. Primary thrombophilia in Mexico III. A prospective study of the sticky platelet syndrome. Clin Appl Thromb Hemost 2002; 8: 273-277.

  11. Parra-Ortega I, Ruiz-Argüelles GJ. Trombofilia multifactorial en México: Descripción de 18 pacientes mestizos mexicanos con el síndrome de las plaquetas pegajosas. Med Inter Mex 2006; 22: 93-96.

  12. Lazo-Lagner A. Síndrome de plaquetas pegajosas. Rev Invest Clín 2004; 56 (1): 103-104.

  13. Kauhansky K. Trombopoietin: The primary regulator of production. Blood 1995; 86: 419-431.

  14. Monroe DM, Hoffman M, Oliver JA. Platelet activity of highdose factor VIIa is dependent of tissue. Br J Haematol 1997; 99: 542-547.

  15. Kjalke M, Ezban M, Monroe D. High- dose factor VIIa increases initial thrombin and mediates master platelet activation in thrombocytopenia–like conditions in a cell based model system. Br J Haematol 2001; 14: 114-120.

  16. Osterud B. The role of platelets in decrypting monocyte tissue factor. Semin Hematol 2001; 38: 2-8.

  17. Bom VJ, Bertina RM. The contributions of Ca, phospholipids and tissue factor apoprotein to the activation of human blood coagulation factor X by activated factor VII. Biochem J 1990; 265: 327-333.

  18. Andersen JC, Lachant NA, Haggood AS. Sticky platelet syndrome: Prevalence, clinical manifestations, and modulation by coexisting conditions in patients with thrombosis. Blood 1998; 92 (1): 188a.

  19. Goldhaber SZ. Pulmonary embolism. Lancet 2004; 363: 1295–305.

  20. De Stefano V, Rossi E, Paciaroni K, Leone G. Screening for inherited thrombophilia: Indications and therapeutic implications. Haematologica 2002; 87: 1095-1108.

  21. Williamson D, Brown K, Luddington R, Baglin C, Baglin T. Factor V Cambridge: A new mutation (Arg306—>Thr) associated with resistance to activated protein C. Blood 1998: 91: 1140-1144.

  22. Gutierrez-Tous MR. Trombofilia, ¿cuándo, qué pruebas y a quién? Sem Fund Esp Reumatol 2005; 6: 133-143.

  23. Martínez-Murillo C, Quintana GS, Ambriz FR, Hernández PM. El problema trombótico en México. Rev Hematol 2000; 1: 17-22.

  24. Rosendaal FR. Thrombosis in the young: Epidemiology and risk factors: a focus onvenous thrombosis. Thromb Haemost 1997; 78: 1-6.

  25. Beltrán E, Linares P, Castaño S. El síndrome de la plaqueta pegajosa. Primer reporte de casos en niños en Colombia y revisión de la literatura. Pediatría 2002; 37: 15-21.

  26. Parra-Ortega I, Estrada-Gómez RA, Ruiz-Argüelles GJ. Síndrome de las plaquetas pegajosas, la condición de trombofilia heredada más frecuente en pacientes mexicanos. Medicina Universitaria 2007; 9 (34): 20-23.

  27. Ruiz-Argüelles GJ, Ruiz DGJ, López MB. El «síndrome de las plaquetas pegajosas», una causa frecuente pero ignorada de trombofilia. Rev Invest Clin 2002; 54: 394-396.




2020     |     www.medigraphic.com