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Medicina Universitaria

2008, Number 40

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Med Univer 2008; 10 (40)

Carotideal atherosclerosis in patients with rheumatoid arthritis and rheumatoid nodules

Galarza DDÁ, Esquivel VJA, Garza EMA

Language: Spanish
References: 53
Page: 131-137
PDF size: 304.12 Kb.


ABSTRACT

Objective: To investigate the correlation between the presence of rheumatoid nodules and intima-media thickness of the carotid arteries as a surrogate for atherosclerosis.
Material and methods: Observational and transversal study including 124 patients with diagnosis of rheumatoid arthritis attending the Rheumatology Service of the “Dr. José Eleuterio González” Hospital from 2005 to 2006. There were two groups on the study, 62 with rheumatoid nodules and 62 without rheumatoid nodules, both matched for age and gender. A complete medical history, erythrocyte sedimentation rate, anti-CCP (Anti Citrullinated Cyclic Peptide) antibodies, rheumatoid factor latex test and Carotid Doppler ultrasound scanning were done in each patient.
Results: 89% were female. There was a prevalence of carotid plaque of 57 % in the study population, superior to the one reported in literature, both in caucasian patients with rheumatoid arthritis (44%) as in control subjects (15%). There was a statistically significant association between carotid plaque and age, hypertension, systolic pressure and abdominal circumference.
The mean thickness of the intima-media of the carotid arteries in rheumatoid patient with atherosclerosis was 0.08564 cm. (± 0.02041).
There was no statistically significant association between lab parameters and the presence of carotid plaque.
Conclusions: Rheumatoid nodules were not associated with the presence of either plaque or intima-media thickness of the carotids arteries in patients with rheumatoid arthritis.


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