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Colegio de Medicina Interna de México.

2011, Number 1

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Med Int Mex 2011; 27 (1)

Inhibidores directos de trombina

Carrillo ER, Arias DCR, Sánchez RD

Language: Spanish
References: 88
Page: 38-51
PDF size: 334.38 Kb.


ABSTRACT

Direct thrombin inhibitors are selective inhibitors of this enzyme. Direct thrombin inhibitors inactivate thrombin without requiring any plasma cofactor, inhibit both free and fibrin-bound thrombin, and do not appreciably bind to plasma proteins. This review will report on the mechanism of action and clinical pharmacology of direct antithrombin agents and on the results of the clinical trials performed with direct thrombin inihibitors.


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