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Órgano Oficial del Instituto de Ciencias de la Salud, Hospital Escuela y Facultad de Medicina-Xalapa

2008, Number 1

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Rev Med UV 2008; 8 (1)

Polymorphism analysis of NRAMP 1 gen and genetic susceptibility to tuberculosis in Coyopolan municipio de Ixhuacan de los Reyes population

Lara RJA, Contreras HS, Gamboa FE, Andrade BAC, López HS, Carranza GD, Méndez PA

Language: Spanish
References: 10
Page: 14-18
PDF size: 434.18 Kb.


ABSTRACT

There are observations that suggest a significant role of genetic factors in innate resistance to infection by Mycobacterium tuberculosis. What the human groups characterized by resistance to the disease have in common is that their ancestors lived in densely populated areas and cities with rife tuberculosis, as was true in Western Europe, where tuberculosis probably began. The populations with the highest susceptibility are those whose origins are prehispanic cultures, which were once free of tuberculosis. Using this theory of genetics susceptibility, the analysis group for the study of polymorphism of NRAMP 1 gene is a group from Coyopolan, community in the County of Ixhuacán of the Reyes, Veracruz. The group consists of 22 patients with the progressive disease and 24 family contact samples. The study of polymorphism of the exon 8 from NRAMP 1 gene in this population is important. It has the finality of demonstrating if this gene is important in the resistance of the bactericide capacity of the pulmonary alveolar and granulomas macrophages.


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