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ISSN 0185-3252 (Print)
Revista de la Asociación Médica del Centro Médico ABC

2010, Number 4

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An Med Asoc Med Hosp ABC 2010; 55 (4)

Factors associated with differentiated thyroid carcinoma. Series of 400 cases

Kunz MW, Mismar A, Ahmad R, Berti P, Gallen D, Miccoli P

Language: Spanish
References: 32
Page: 179-184
PDF size: 157.92 Kb.


ABSTRACT

Background: Thyroid nodules are being diagnosed with increased frequency, but only a small fraction is malignant. Determination of the biologic nature of these lesions is of foremost importance. There are multiple clinical factors associated with malignant thyroid nodules and with the increased accuracy of current diagnostic methods it is imperative to redefine the role of these clinical characteristics. Methods: Prospective, observational and longitudinal study of patients submitted to primary thyroid surgery at the 2nd Department of General Surgery at the University of Pisa, Italy from april the 1st until june 30 2008. We identified factors associated with malignant thyroid nodules. Results: We included 400 patients (170 with cancer) and identified the statistically significant associations: age (‹ 50 years), greater concentrations of thyrotropin, smaller thyroid volume, solitary nodules and cervical lymph nodes. It was impossible to define a useful formula to predict malignancy based upon the reviewed variables and logistic regression. Conclusions: Traditionally accepted clinical characteristics associated with thyroid carcinoma are being displaced by current diagnostic methods. Thyroid cytology is the most useful single study to determine the nature of thyroid nodules and sequential immunohistochemical methods might provide further refinement to the follicular lesion diagnostic category.


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