Mondragón ÁME

Language: Spanish
References: 12
Page: 167-174
PDF size: 339.21 Kb.

ABSTRACT

In order to prevent laryngeal neoplasms it is important to identify mechanisms constituting the base of carcinomatous degeneration and to discover early the precancerous clinical forms. Risk factors are genetic, environmental, infectious, local and dietetic. Diagnosis may be done with tomography of optic coherence, which nowadays is a diagnostic method that predicts with high sensitivity and specificity the presence of precancerous lesions and laryngeal carcinoma in situ; even though it has little capacity of penetration. Another method used currently is the self-fluorescent endoscopy, which has been developed to increase the diagnostic accuracy during microlaryngoscopy. About treatment, in 2006 Almadori developed a pilot study in phase IIA, based on his study in which he demonstrated the efficacy of folates in patients with latyngeal precancerous lesions; although this study is preliminary, it gives us a very satisfactory entrance of conservative treatment of these lesions without the adverse effects so severe of vitamin A derivatives.

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