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ISSN 2007-5294 (Print)
Confederación Nacional de Pediatría de México, A. C. (CONAPEME)

2010, Number 1

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Pediatr Mex 2010; 12 (1)

Prevalence of resistance to insulin and metabolic syndrome in obese children attending the Obesity Clinic of the Sinaloa Pediatric Hospital

Martínez GJJ, Rojas PGG, León SNM

Language: Spanish
References: 22
Page: 18-22
PDF size: 186.83 Kb.


ABSTRACT

Objectives: to determine the prevalence of insulin resistance (IR) and metabolic syndrome (MS) and the relationship of acanthosis nigricans (AN) with IR in obese children attending in the Nutrition Clinic at Children’s Hospital of Sinaloa.
Material and methods: a prospective and cross study. We included children between 3 to 18 years old with body mass index greater than 95th percentile for age and sex. We studied anthropometric, biochemical, and clinical variables. IR was defined as HOMA-IR (Homeostasis Model Assessment for Insulin Resistance) ≥ 3.16 mUI / mL and MS to the presence of three or more indicators. We used descriptive statistics, t Student test, ANOVA, chi square and logistic regression analysis with p ‹0.05 statistically significant.
Results: the prevalence of IR in 97 children was 49.5% and 37.1% for MS, was not statistically significant by sex. Children with MS had a risk factor (odds ratio) 3.3 (95% CI 1.35 - 8.29) for IR with statistically significant (p=0.009). The AN was present in 72.2%, was higher in males but not statistically significant. AN association with IR was statistically significant (p = 0.015), and patients with AN had risk factor of 3.5 (95% CI 1.28-9.49) for IR.
Conclusions: The prevalence of insulin resistance and metabolic syndrome in our study was similar to other reports and acanthosis nigricans as in other studies was an independent risk factor for insulin resistance.


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