2009, Number 09
<< Back Next >>
Ginecol Obstet Mex 2009; 77 (09)
Radiological control intraoperatory of a surgical piece in non palpable breast lesions
Ruvalcaba LE, Espejo FR, Bautista PV, Madero PL, Capurso GM, Serratos GJE, Guisa HF, Rodríguez CS
Language: Spanish
References: 36
Page: 407-418
PDF size: 443.56 Kb.
ABSTRACT
Background: nonconcrete the mammary injuries are frequent in programs of detection of breast cancer, estereotaxic or ecographic marking is required to realize its split. The intrasurgical radiation control of the surgical piece is indispensable to evaluate the margins of the mammary cancer.
Objective: to determine the effectiveness of the intrasurgical radiation control of the surgical piece in nonconcrete mammary injuries to diminish the surgical reinterventions to extend margins.
Patients and method: women with nonconcrete mammary injuries to those who biopsy by split became, previous marking and intraoperating radiation control of the surgical piece to value margins (suitable margin the same or major of 10 mm, smaller inadequate margin of 10 mm). Intrasurgical reesicion in inadequate radiological margins became. The demographic characteristics, masto-ecographics images, histopathology of the injuries and the radiological-histopatológica correlation of the margins studied. Cross-sectional, prospective and descriptive study.
Results: 103 patients with 113 nonconcrete mammary injuries included themselves, with age average of 51,35 (32-73) years. In all the injuries the intrasurgical radiation control became of the surgical piece. The prevalence of mammary cancer was of 28,3% (32/113), that corresponds to stellar images (42,8%), suspicious microcalcifications with density (39,2%), microcalcifications (31,2%) and nodules (20%). Of the 32 cancers, 16 had inadequate radiological margins that required intraoperating reescision; suitable histopatologic margins in 100% were obtained (16/16). The 16 (62,5%) cancers without intraoperating reescisión by suitable radiological margins had suitable histopatologic margins and 37,5% (6/16) inadequate ones that required surgical reintervención to control the margins. The discrepancy between margins was related to microcalcifications in 83.3% of the injuries.
Conclusions: the intrasurgical radiation control of the surgical piece is effective to evaluate margins; the intrasurgical reescisión changed inadequate margins to suitable in 50% (16/32) of the cancers; only 18,7% (6/32) of the total of cases required another surgery to control the margins.
REFERENCES
Tabár L, Fagerberg CJ, Gad A, Baldetorp L, et al. Reduction in mortality from breast cancer after mass screening with mammography. Randomised trial from the Breast Cancer Screening Working Group of the Swedish National Board of Health and Welfare. Lancet 1985;1:829-32.
Cortesi L, Chiuri VE, Ruscelli S, Bellelli V, et al. Prognosis of screen-detected breast cancers: results of a population based study. BMC Cancer 2006;6:17.
Ohnuki K. Mammographic screening for non-palpable breast cancer in Japan. Breast Cancer 2005;12:258-66.
Venta Luz A. Radiología e imagen diagnóstica y terapéutica. Mamografía. Intervención e imagen. Philadelphia: Lippincott Williams & Wilkins, 2000.
Fracheboud J, de Koning HJ, Beemsterboer PM, Boer R, et al. Nation-wide breast cancer screening in The Netherlands: results of initial and subsequent screening 1990-1995. National Evaluation Team for Breast Cancer Screening. Int J Cancer 1998;75:694-8.
Hernández CNI, Sandoval GF, Hernández GM, Torres LA, et al. Lesiones mamarias no palpables sospechosas de malignidad. Correlación radiológica-quirúrgica (Hospital General de México, OD). Gamo 2007;6(2):42-46.
Castellanos AR, Aceves GI, Santillán RJH, Vázquez ZVM, y col. Lesiones mamarias no palpables: biopsia mediante marcaje con arpón. Gamo 2006;5(2):40-43.
Silverstein MJ, Lagios MD, Groshen S, Waisman JR, et al. The influence of margin width on local control of ductal carcinoma in situ of the breast. N Engl J Med 1999;340(19):1455-61.
Silverstein MJ. The University of Southern California/Van Nuys prognostic index for ductal carcinoma in situ of the breast. Am J Surg 2003;186:337-43.
Meric F, Mirza NQ, Vlastos G, et al. Positive surgical margins and ipsilateral breast tumour recurrence predict diseasespecific survival after breast conserving therapy. Cancer 2003;97:926-33.
MacDonald HR, Silverstein MJ, Mabry H, Moorthy B, et al. Local control in ductal carcinoma in situ treated by excision alone: incremental benefit of larger margins. Am J Surg 2005;190:521-5.
Breast Cancer NCCN Clinical Practice Guidelines in Oncologyv1. 2009, National Cancer Comprehensive Network. Dirección URL: .
Singletary SE. Surgical margins in patients with early stage breast cancer treated with breast conservation therapy. Am J Surg 2002;184:383-93.
Cheng L, Al-Kaisi NK, Gordon NH, Liu AY, et al. Relationship between the size and margin status of ductal carcinoma in situ of the breast and residual disease. J Natl Cancer Inst 1997;89(18):1356-60.
Kaur N, Petit JY, Rietjens M, Maffini F, et al. Comparative study of surgical margins in oncoplastic surgery and quadrantectomy in breast cancer. Ann Surg Oncol 2005;12(7):539-45.
Miller AR, Brandao G, Prihoda TJ, Hill C, et al. Positive margins following surgical resection of breast carcinoma: analysis of pathologic correlates. J Surg Oncol 2004;86:134-40.
Balch GC, Mithani SK, Simpson JF, Kelley MC. Accuracy of intraoperative gross examination of surgical margin status in women undergoing partial mastectomy for breast malignancy. Am Surg 2005;71:22-28.
Dillon MF, Hill ADK, Quinn CM, McDermott EW, O’Higgins N. A pathologic assessment of adequate margin status in breastconserving therapy. Ann Surg Oncol 2006;13(3):333-9.
Neuschatz AC, DiPetrillo T, Steinhoff M, Safaii H, et al. The value of breast lumpectomy margin assessment as a predictor of residual tumor burden in ductal carcinoma in situ of the breast. Cancer 2002;94(7):1917-24.
Hunt KK, Meric-Bernstam F. In: Hunt KK, Robb GL, Strom EA, Ueno NT, eds. Surgical options for breast cancer. 2nd ed. New York: Breast Cancer. M.D. Anderson Cancer Care series. Springer, 2008;pp:198-234.
Gibson GR, Lesnikoski BA, Yoo J, Mott LA, et al. A comparison of ink-directed and traditional whole-cavity re-excision for breast lumpectomy specimens with positive margins. Ann Surg Oncol 2001;8(9):693-704.
Chagpar A, Yen T, Sahin A, Hunt KK, et al. Intraoperative margin assessment reduces reexcision rates in patients with ductal carcinoma in situ treated with breast-conserving surgery. Am J Surg 2003;186:371-7.
Klimberg VS, Westbrook KC, Korourian S. Use of touch preps for diagnosis and evaluation of surgical margins in breast cancer. Ann Surg Oncol 1998;5:220-6.
Saarela AO, Paloneva TK, Rissanen TJ, Kiviniemi HO. Determinants of positive histologic margins and residual tumor after lumpectomy for early breast cancer: a prospective study with special reference to touch preparation cytology. J Surg Oncol 1997;66:248-53.
Creager AJ, Shaw JA, Young PR, Geisinger KR. Intraoperative evaluation of lumpectomy margins by imprint citology with histologic correlation. A community hospital experience. Arch Pathol Lab Med 2002;126:846-8.
Zafrani B, Contesso G, Eusebi V, et al. Guidelines for the pathological management of mammographically detected breast lesions. Breast 1995;4:52-56.
Lee CH, Carter D. Detecting residual tumor after excisional biopsy of impalpable breast carcinoma: efficacy of comparing preoperative mammograms with radiographs of the biopsy specimen. AJR Am J Roentgenol 1995;164:81-86.
Solin LJ, Fowble BL, Schultz DJ, Goodman RL. The significance of the pathology margins of the tumor excision on the outcome of patients treated with definitive irradiation for early stage breast cancer. Int J Radiat Oncol Biol Phys 1991;21:279-87.
Barroso BS, Segura RLA, Rubio V, Alvarado CI, y col. Radiografía del espécimen quirúrgico como parte de la consulta intraoperatoria para evaluar el margen quirúrgico en mujeres con cáncer de mama sometidas a tratamiento conservador de la mama: estudio piloto. Gamo 2006.
Hemmer PHJ, Klaase JM, Mastboom WJB, Gerritsen JJGM, et al. The continued utility of needle localised biopsy for nonpalpable breast lesions. Eur J Surg Oncol 2004;30:10-14.
Rodríguez-Cuevas S, et al. First breast cancer mammography screening program in Mexico. Initial results 2005-2006. Breast Journal 2009;15(6). In press. Accepted for publication, August 12, 2008.
Papa MZ, Zippel D, Koller M, Klein E, et al. Positive margins of breast biopsy: is reexcision always necessary? J Surg Oncol 1999;70:167-71.
Homer MJ, Berlin L. Malpractice issues in radiology. Radiography of the surgical breast biopsy specimen. AJR Am J Roentgenol 1998;171:1197-9.
Rebner M, Pennes DR, Baker DE, Adler DD, Boyd P. Two-view specimen radiography in surgical biopsy of nonpalpable breast masses. AJR Am J Roentgenol 1987;149:283-5.
Champ CS, Mason CH, Coghill SB, Robinson M. A perspex grid for localization of non-palpable mammographic lesions in breast biopsies. Histopathology 1989;14:311-5.
Waddell BE, Stomper PC, DeFazio JL, Hurd TC, Edge SB. Postexcision mammography is indicated after resection of ductal carcinoma-in-situ of the breast? Ann Surg Oncol 2000;7(9):665-8.