Navarrete FG, Santa CFJ, Peña OJ, Domínguez MA, Venadero AF, Cardona HMÁ, García CSJ

Language: Spanish
References: 15
Page: 75-80
PDF size: 387.46 Kb.

ABSTRACT

Pytiriasis lichenoides represents a group of inflammatory skin disorders of unknown etiology associated with excessive proliferation of T cells. Pytiriasis lichenoides varioliformes acute (PLEVA/Mucha-Habermann disease) and Pytiriasis lichenoides chronic (PLC), are both consider in the same spectrum of this disease. Febrile ulceronecrotic entity is a rare disorder and different from PLEVA by rapid progression of necrotic papules to large coalescent ulcers with necrotic crusts and hemorrhagic bullae. Besides, systematic manifestations are always present, and includes high fever, sore throat, diarrhea, central nervous system symptoms, intersticial pneumonitis, splenomegaly, sepsis, megaloblastic anemia, conjunctival ulcers and even death. There are multiple options for treatment but none of choice. We consider the case of a 42 year old woman with Febrile ulceronecrotic PLEVA, with a satisfactory evolution treatment with pentoxifylline.

REFERENCES

1. Bowers S et al. Pityriasis lichenoides and its subtypes. J Am Acad Dermatol 2006; 55: 557-562.

2. Khachemoune A et al. Pityriasis Lichenoides. Am J Clin Dermatol 2007; 8: 29-36.

3. Weedon D. Piel Patología. España. Marban Libros, S.L. 2002: 210-212.

4. Lambert WC, Li H, Schwartz A. Parapsoriasis. En: Torres Lozada V, et al. Dermatología Práctica Ibero-Latinoamericana. México: Nieto Editores, 2005: 491.

5. Pradeep FS. A Clinical and Histopathological Study of Pytiriasis Lichenoides. Indian J Dermatol Venereol Leprol 2007; 73: 100-102.

6. Sotiriou E et al. Febrile Ulceronecrotic Mucha-Habermann Disease: A Case Report and Review of the literature. Acta Derm Venereol 2008; 88: 350-355.

7. Tsianakas A et al. Transition of pityriasis lichenoides et varioliformis acute to febrile ulceronecrotic Mucha–Habermann disease is associated with elevated serum tumour necrosis factor-a. Br J Dermatol 2005; 152: 794-799.

8. Smith J JL. Febrile ulceronecrotic Mucha-Habermann disease associated with herpes simplex virus type 2. J Am Acad Dermatol 2009; 60: 149-152.

9. Pelagay PJ et al. Pitiriasis liquenoide. Med Cutan Iber Lat Am 2007: 35: 167-173.

10. Cozzio A et al. Febrile ulceronecrotic Mucha-Habermann disease with clonality: A cutaneous T-cell lymphoma entity? J Am Acad Dermatol 2004; 51: 1014-1017.

11. Tomasini D et al. Pytiriasis Lichenoides: a cytotoxic T-Cell-mediated skin disorder. Evidence of Human parvovirus B19 in nine cases. J Cutan Pathol 2004; 31: 531-538.

12. Natsuho I et al. Febrile ulceronecrotic Mucha-Habermann’s disease managed with methylprednisolone semipulse and subsequent methotrexate therapies. J Am Acad Dermatol 2003; 49: 1142-1147.

13. Aydogan K et al. Narrowband UVB (311 nm, TL 01) phototherapy for pytiriasis lichenoides. Photodermatol, Photoimmunol Photomed 2008; 24: 128-133.

14. Mássimo JA. Pitiriasis liquenoide. Rev Hosp Niños B. Aires 2008: 227: 84-88.

15. Helmbold P et al. Self-limited variant of febrile ulceronecrotic Mucha-Habermann disease with polyclonal T-cell receptor rearrangement. J Am Acad Dermatol 2006: 54: 1113-1116.