Hernández RJ

Language: Spanish
References: 22
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ABSTRACT

This review has the purpose to point out the contributions that microarrays technology can offer to the public health area. Microarrays will be difficult to be implemented in routine analysis to population scale, due to their high cost. However, because of the great amount of information that it is possible to obtain, microarrays can facilitate the detection of biological markers that may allow the timely diagnosis of infectious or chronic-degenerative diseases, or the identification of new target molecules to apply more specific treatments. These new markers could then be used in massive form in population based studies or epidemic surveillance. The utility of this technique will depend on the study questions, on the appropriate design of the hybridization plates, which play a very important role in regard to the sequences characteristics to “print ”in the plates, and the statistical analysis of the results. Applying this technology, it has been possible to differentiate among several cancer types, it has been possible to detect disease causing divergent vaccine poliovirus, and it has been detected both in pathogen agents and in host cells, groups of genes that mediate the pathogenesis of some illnesses.

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