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2010, Number 4

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Rev Mex Anest 2010; 33 (4)

Epidural dexmedetomidine vs fentanyl in abdomen and lower limb surgery

Oriol-López SA, Hernández-Bernal CE

Language: Spanish
References: 22
Page: 179-186
PDF size: 426.15 Kb.


ABSTRACT

The α2 agonists by their properties (liposolubility and high affinity by the adrenergic receptors), are used like adjuvant in anesthesia. The analgesia, takes place by activation of spinal colinergics neurons, release to acetilcoline and nitric oxide (NOT), the Dexmedetomidine (D) shows greater affinity in membranes of the spinal marrow that in the brain, is 5 times more effective epidural than systemic. Objective: to demonstrate that the addition of D 1 µg/kg to the local anesthetic, administering it by epidural route, diminishes the amount used of this one, produces homodynamic stability, analgesia, without respiratory depression, when comparing it with the association of fentanyl (F) plus local anesthetic. Results: 82 patients, scheduled abdominal or limb minor surgery, randomized in 2 groups included themselves (D or F), is used epidural less D, in relation to the systemic doses, also the less local anesthetic in D that in F (p ‹ 0.05). There are reductions in FC and PA in D, as much between groups as intragroup (p ‹ 0.05), although do not require of drug therapy. Without respiratory depression, with qualifications of 3 and 4 in the Ramsay´s scale.


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