Sánchez-Nava J, Mejía-Sánchez MR, Sánchez-Michaca VJ, Jiménez-Urueta PS, Ramírez-Hernández I, Lezama-del Valle P

Language: Spanish
References: 23
Page: 312-316
PDF size: 560.34 Kb.

ABSTRACT

Introduction. The effectiveness of intralesional sclerotherapy of lymphangioma with OK-432 (Picibanil) has been proved in several clinical studies. The aim of our study was to review the effectiveness of sclerotherapy of benign tongue cysts with Picibanil as an alternative method to surgical excision. A prospective observational study was carried out to assess the effects of Picibanil on tongue cysts.
Material and Method. Between 1995 and 2007 we studied 300 patients with lymphangioma. Twelve of them had tongue cysts which were treated with intralesional application of Picibanil with a dose ranging from 0.01 mg/mL to 0.03 mg/mL.
Results. The 12 patients showed good results. In both clinically and by ultrasonograph. However complete regression of the cysts occurred in five cases, while in seven cases the cysts showed atrophy for which reason the remaining cyst was surgically removed. No significant complications after sclerotherapy with Picibanil was observed.
Conclusion. OK-432 (Picibanil) is a safe and effective primary method for sclerotherapy of tongue cysts; its use precludes surgical removal in special cases.

REFERENCES

1. Kennedy TL, Whitaker M, Pellitteri P et al. Cystic hygroma/lymphangioma: a rational approach to manegement. Laringoscope. 2001;111:1929-37.

2. Kennedy TL. Cystic hygroma/lymphangioma a rare and still unclear entity. Laryngoscope. 1989;991-10.

3. Charabi B, Brtlau P, Billie M et al. Cystic hygroma/lymphangioma: a rare and still unclear entity. Laryngoscope. 1989;99:1-10.

4. Sanliap I, Karmak I, Tanyel FC et al. Cystic Hygroma of the head and neck a long term follow-up of 44 cases. Acta Otolaryngol. 2000;543:248-50.

5. Smith R, Burke D, Sato Y, Poust RI, Kimura Kbauman NM. OK-432 therapy for lymphangiomas. Arch Otolaryngol Head Neck Surg. 1996;122:1195-9.

6. Ogita S, Tsuto T, TokiwaK, Takahasi T. Intracystic injection of OK-432 a new esclerosing therapy for cystic hygroma in children. Br J Sur. 1987;74:690-1.

7. Ogita S, Tsuto T, TokiwaK, Takahashi T. Intracystic injection of OK-432 therapy for lymphangiomas in children: why and how does it work? J Pediatr Surg. 1996; 31:477-80.

8. Mulliken JB, Glowacki J. Haemangiomas and vascular malformations in infants and children: A classification based on endothelial characteristics. Plast Reconsr Surg. 1982;69:41-23.

9. Banieghbal B, Davies MR. Guidelines for the successful treatment of lymphangioma with OK-432. Eur J Pediatr Surg. 2003;13:103-7.

10. Gleason TJ, Yuh WT, Tali ET, Harris KG, Mueler DP. Traumatic cervical cyst lymphangioma in an adult. Ann Otol Rhinol Laryngol. 1993;102:564-6.

11. Mejía SM, Sánchez NJ, Duarte VJC. Linfangiomas tratados con OK432 intratumoral en niños. Experiencia con 12 casos. Acta Pediatr Mex. 1998;19:143-7.

12. Wiggs WJ, Sismanis A. Cystic hygroma in the adult: Two cases report. Otolaryngol Head Neck Surg. 1994;110:239-41.

13. Morley SE, Ramesar KC, Mc Leod DA. Cystic hygroma in an adult: a case report. J R Coll Surg Edim. 1999;44:57-8.

14. Antoniades K, Kiziridou A, Psimopoulou M. Traumatic cervical cystic hygroma. Ind J Oral Maxillofac Sur. 2000;29:47-48.

15. Riechelmann H, Muehlfay G, Keck T, Mattfeld, Rettinger G. Total subtotal, and partial surgical renoval of cervicofacial lymphangiomas. Arch Otolaryngol Head Neck Surg. 1999;125:643-8.

16. Luzzatto C, Midrio P, Tchaprassian Z, Guglielmi M. Sclerosing of lymphangiomas with OK-432. Arch Dis Child. 2000;82:316-8.

17. Castañon M, Margarit J, Carrasco R, Vancellis M, Albert A, Morales L. Long term follow-up of nineteen cystic lymphangiomas treated with fibrin sealan. J Pediatr Surg. 1999;48:1276-9.

18. Farmand M, Kuttemberg J. A new therapeutic concept for the treatment of cystic hygroma. Oral Sur Med Oral Pathol Oral Radiol Endod. 1996;81:389-95.

19. Zhong PQ, Zhi FX, Li R, XueJL,Shu GY. Long term results of intratumorous bleomycin-A5 injection for head and neck lymphangioma. Oral Sur Oral Med Oral Pathol. 1995;82:139-44.

20. Katsumo S, Ezawa S, Minemura T. Excision of cervical cystic lymphangioma using injection of hidrocolloid dental impression material. J Oral Maxillofac Surg. 1999;28:295-6.

21. Rautio R, Keski-Nisula L, Laranne J, Laasonen E. Treatment of lymphangioma with OK-432(Picibinil). Cradiovasc Intervent Radiol. 2003;26:31-6.

22. Sung MW, Lee DW, Kim DY, Hwang Ch, Park SW, Kim KH. Sclerotherapy with picibinil (OK-432) for the congenital lymhatic malformation in the head and neck. Laringoscope. 2001;111:1430-3.

23. Giguere CM, Bauman N, Sato Y, Burke DK, Greinwald JH, Pransky S et al. Treatment of lymphangiomas with OK-432 (picibinil) sclerotherapy: a prospective multi-institutinal trial. Arch Otolaryngol Head Neck Surg. 2002;128:1137-44.